FES - Gene info - The Human Protein Atlas

Gene name

FES (HGNC Symbol)

Synonyms

FPS

Description

FES proto-oncogene, tyrosine kinase (HGNC Symbol)

Entrez gene summary

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]

Chromosome

Cytoband

q26.1

Chromosome location (bp)

90883695 - 90895776

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000182511 (version 78.38)

Entrez gene

2242

UniProt

P07332 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FES-001

ENSP00000331504
ENST00000328850

P07332
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P07332 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
A0A024RC92 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000632}
H0YNN8 [Target identity:20%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000454089}
E7EMJ7 [Target identity:17%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000392696}
E9PGC7 [Target identity:13%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000395425}
Q4JFK7 [Target identity:8%; Query identity:100%]
C-fes/fps protein {ECO:0000313|EMBL:AAA53105.2}
C9J3W6 [Target identity:5%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000410477}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010976 [positive regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034987 [immunoglobulin receptor binding]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0043304 [regulation of mast cell degranulation]
GO:0045595 [regulation of cell differentiation]
GO:0045639 [positive regulation of myeloid cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:2000145 [regulation of cell motility]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]

822

93.5

FES-005

ENSP00000377837
ENST00000394300

P07332
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P07332 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
Q4JFK7 [Target identity:9%; Query identity:100%]
C-fes/fps protein {ECO:0000313|EMBL:AAA53105.2}
C9J3W6 [Target identity:5%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000410477}

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GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010976 [positive regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034987 [immunoglobulin receptor binding]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0043304 [regulation of mast cell degranulation]
GO:0045595 [regulation of cell differentiation]
GO:0045639 [positive regulation of myeloid cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:2000145 [regulation of cell motility]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]

764

86.7

FES-006

ENSP00000377839
ENST00000394302

E7ENM8
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E7ENM8 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000632}
Q4JFK7 [Target identity:10%; Query identity:100%]
C-fes/fps protein {ECO:0000313|EMBL:AAA53105.2}
C9J3W6 [Target identity:6%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000410477}

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Predicted intracellular proteins
Cytoskeleton related proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018108 [peptidyl-tyrosine phosphorylation]

681

76.8

FES-007

ENSP00000410477
ENST00000416779

C9J3W6
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C9J3W6 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000410477}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

4.8

FES-010

ENSP00000392696
ENST00000452243

E7EMJ7
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E7EMJ7 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000392696}
E9PGC7 [Target identity:77%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000395425}
Q4JFK7 [Target identity:48%; Query identity:100%]
C-fes/fps protein {ECO:0000313|EMBL:AAA53105.2}
C9J3W6 [Target identity:28%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000410477}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

147

16.9

FES-011

ENSP00000395425
ENST00000443697

E9PGC7
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E9PGC7 [Target identity:99%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000395425}
Q4JFK7 [Target identity:61%; Query identity:100%]
C-fes/fps protein {ECO:0000313|EMBL:AAA53105.2}
C9J3W6 [Target identity:36%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000410477}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

115

FES-017

ENSP00000414629
ENST00000414248

P07332
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P07332 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
Q4JFK7 [Target identity:10%; Query identity:100%]
C-fes/fps protein {ECO:0000313|EMBL:AAA53105.2}
C9J3W6 [Target identity:6%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000410477}

Show » « Hide

GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010976 [positive regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034987 [immunoglobulin receptor binding]
GO:0035091 [phosphatidylinositol binding]
GO:0042127 [regulation of cell proliferation]
GO:0043304 [regulation of mast cell degranulation]
GO:0045595 [regulation of cell differentiation]
GO:0045639 [positive regulation of myeloid cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:2000145 [regulation of cell motility]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]

694

78.6

FES-018

ENSP00000400868
ENST00000444422

P07332
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P07332 [Direct mapping]
Tyrosine-protein kinase Fes/Fps
H0YNN8 [Target identity:22%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000454089}
E7EMJ7 [Target identity:19%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000392696}
E9PGC7 [Target identity:15%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000395425}
Q4JFK7 [Target identity:9%; Query identity:100%]
C-fes/fps protein {ECO:0000313|EMBL:AAA53105.2}
C9J3W6 [Target identity:5%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000410477}

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752

85.5

FES-020

ENSP00000454089
ENST00000559355

H0YNN8
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H0YNN8 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000454089}
E7EMJ7 [Target identity:86%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000392696}
E9PGC7 [Target identity:67%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000395425}
Q4JFK7 [Target identity:42%; Query identity:100%]
C-fes/fps protein {ECO:0000313|EMBL:AAA53105.2}
C9J3W6 [Target identity:24%; Query identity:100%]
Tyrosine-protein kinase Fes/Fps {ECO:0000313|Ensembl:ENSP00000410477}

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Predicted intracellular proteins
Cancer-related genes
Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]

169

19.4

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.