SHMT2

GENE INFORMATION

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Gene name

SHMT2 (HGNC Symbol)

Synonyms

SHMT

Description

Serine hydroxymethyltransferase 2 (mitochondrial) (HGNC Symbol)

Entrez gene summary

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

12

Cytoband

q13.3

Chromosome location (bp)

57229327 - 57234935

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000182199 (version 78.38)

Entrez gene

6472

UniProt

P34897 (UniProt - Evidence at protein level)

neXtProt

NX_P34897

Antibodypedia

SHMT2 antibodies
 

PROTEIN VIEW

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 « 
 
SHMT2-001
 
SHMT2-005
 
SHMT2-008
 
SHMT2-009
 
SHMT2-015
 
SHMT2-019
 
SHMT2-021
 
SHMT2-022
 
SHMT2-023
 
SHMT2-025
 
SHMT2-027
 
SHMT2-028
 
SHMT2-030
 
SHMT2-033
 
SHMT2-038
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SHMT2-001 ENSP00000333667
ENST00000328923
P34897
Show all »
Show » Show » 504 56 No 0
SHMT2-005 ENSP00000406881
ENST00000414700
P34897
Show all »
Show » Show » 483 53.5 No 0
SHMT2-008 ENSP00000413770
ENST00000449049
P34897
Show all »
Show » Show » 483 53.5 No 0
SHMT2-009 ENSP00000452419
ENST00000553474
P34897
Show all »
Show » Show » 483 53.5 No 0
SHMT2-015 ENSP00000452315
ENST00000557487
P34897
Show all »
Show » Show » 494 54.9 No 0
SHMT2-019 ENSP00000450930
ENST00000555634
G3V2Y4
Show all »
Show » Show » 234 25.7 No 0
SHMT2-021 ENSP00000450452
ENST00000557703
G3V241
Show all »
Show » Show » 142 15.8 No 0
SHMT2-022 ENSP00000452161
ENST00000553529
G3V3Y8
Show all »
Show » Show » 147 16.3 No 0
SHMT2-023 ENSP00000450893
ENST00000554310
G3V2W0
Show all »
Show » Show » 160 17.7 No 0
SHMT2-025 ENSP00000452045
ENST00000557427
G3V4X0
Show all »
Show » Show » 159 17.6 No 0
SHMT2-027 ENSP00000451968
ENST00000555773
G3V4T0
Show all »
Show » Show » 149 16.4 No 0
SHMT2-028 ENSP00000452404
ENST00000554975
G3V5L0
Show all »
Show » Show » 215 24 No 0
SHMT2-030 ENSP00000450490
ENST00000557529
Show » Show » 264 28.7 No 0
SHMT2-033 ENSP00000452035
ENST00000556689
G3V4W5
Show all »
Show » Show » 237 26.3 No 0
SHMT2-038 ENSP00000451495
ENST00000556737
G3V3Y8
Show all »
Show » Show » 147 16.3 No 0