POLR2A

GENE INFORMATION

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Gene name

POLR2A (HGNC Symbol)

Synonyms

POLR2, POLRA, RPB1

Description

Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa (HGNC Symbol)

Entrez gene summary

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

p13.1

Chromosome location (bp)

7484366 - 7514618

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181222 (version 78.38)

Entrez gene

5430

UniProt

P24928 (UniProt - Evidence at protein level)

neXtProt

NX_P24928

Antibodypedia

POLR2A antibodies
 

PROTEIN VIEW

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POLR2A-001
 
POLR2A-002
 
POLR2A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

POLR2A-001 ENSP00000480158
ENST00000617998
Show » Show » 1980 218.2 No 0
POLR2A-002 ENSP00000461879
ENST00000572844
P24928
Show all »
Show » Show » 566 63.6 No 0
POLR2A-201 ENSP00000483957
ENST00000621442
P24928
Show all »
Show » Show » 1970 217.2 No 0