NPM1 - Gene info - The Human Protein Atlas

Gene name

NPM1 (HGNC Symbol)

Synonyms

B23, NPM

Description

Nucleophosmin (nucleolar phosphoprotein B23, numatrin) (HGNC Symbol)

Entrez gene summary

This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

Chromosome

Cytoband

q35.1

Chromosome location (bp)

171387116 - 171411137

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181163 (version 78.38)

Entrez gene

4869

UniProt

P06748 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NPM1-001

ENSP00000296930
ENST00000296930

P06748
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P06748 [Direct mapping]
Nucleophosmin
Q9BTI9 [Target identity:77%; Query identity:100%]
NPM1 protein {ECO:0000313|EMBL:AAH03670.2}
E5RI98 [Target identity:37%; Query identity:100%]
Nucleophosmin {ECO:0000313|Ensembl:ENSP00000429485}

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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003676 [nucleic acid binding]
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0006334 [nucleosome assembly]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006950 [response to stress]
GO:0007098 [centrosome cycle]
GO:0007165 [signal transduction]
GO:0007569 [cell aging]
GO:0008104 [protein localization]
GO:0008285 [negative regulation of cell proliferation]
GO:0010826 [negative regulation of centrosome duplication]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030529 [ribonucleoprotein complex]
GO:0030957 [Tat protein binding]
GO:0031616 [spindle pole centrosome]
GO:0032071 [regulation of endodeoxyribonuclease activity]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0042255 [ribosome assembly]
GO:0042393 [histone binding]
GO:0042803 [protein homodimerization activity]
GO:0043023 [ribosomal large subunit binding]
GO:0043024 [ribosomal small subunit binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0046599 [regulation of centriole replication]
GO:0046982 [protein heterodimerization activity]
GO:0051059 [NF-kappaB binding]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0060699 [regulation of endoribonuclease activity]
GO:0060735 [regulation of eIF2 alpha phosphorylation by dsRNA]

294

32.6

NPM1-002

ENSP00000341168
ENST00000351986

P06748
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P06748 [Direct mapping]
Nucleophosmin
E5RI98 [Target identity:41%; Query identity:100%]
Nucleophosmin {ECO:0000313|Ensembl:ENSP00000429485}

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265

29.5

NPM1-003

ENSP00000377408
ENST00000393820

P06748
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P06748 [Direct mapping]
Nucleophosmin
Q9NX34 [Target identity:69%; Query identity:100%]
cDNA FLJ20465 fis, clone KAT06236 {ECO:0000313|EMBL:BAA91188.1}
E5RI98 [Target identity:42%; Query identity:100%]
Nucleophosmin {ECO:0000313|Ensembl:ENSP00000429485}

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259

28.4

NPM1-004

ENSP00000428755
ENST00000517671

P06748
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294

32.6

NPM1-005

ENSP00000429485
ENST00000521672

E5RI98
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E5RI98 [Target identity:100%; Query identity:100%]
Nucleophosmin {ECO:0000313|Ensembl:ENSP00000429485}

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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003676 [nucleic acid binding]

111

11.9

NPM1-007

ENSP00000428647
ENST00000523622

E5RGW4
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E5RGW4 [Target identity:100%; Query identity:100%]
Nucleophosmin {ECO:0000313|Ensembl:ENSP00000428647}

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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0003676 [nucleic acid binding]

6.9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.