OXTR

GENERAL INFORMATION

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Gene name

OXTR

Gene description

Oxytocin receptor

Protein class

FDA approved drug targets
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (fallopian tube, ovary)
GTEx:Group enriched (breast, endometrium)

Protein evidence

Evidence at protein level

Protein localization

Most normal cells showed weak to moderate cytoplasmic and/or nuclear positivity. Strong staining was observed in trophoblasts, epididymis, respiratory epithelial cells of bronchus and subsets of renal tubular cells. Pancreas, salivary glands and Purkinje cells of cerebellum were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB022700
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (fallopian tube, ovary)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (breast, endometrium)

Organ

Expression



GENE INFORMATION

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Gene name

OXTR

Synonyms

Description

Oxytocin receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p25.3

Chromosome location (bp)

8750408 - 8769628

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180914 (version 78.38)

Entrez gene

5021

UniProt

P30559 (UniProt - Evidence at protein level)

neXtProt

NX_P30559

Antibodypedia

OXTR antibodies


PROTEIN BROWSER

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ENST00000316793
 
ENST00000431493
 
ENST00000449615
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OXTR-001 ENSP00000324270
ENST00000316793
P30559
Show all »
Show » Show » 389 42.8 No 7
OXTR-002 ENSP00000414828
ENST00000431493
C9JQC4
Show all »
Show » Show » 43 4.3 No 0
OXTR-004 ENSP00000389587
ENST00000449615
C9JN09
Show all »
Show » Show » 92 9.7 No 1