GPBAR1

GENE INFORMATION

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Gene name

GPBAR1 (HGNC Symbol)

Synonyms

BG37, GPCR, GPCR19, GPR131, M-BAR, MGC40597, TGR5

Description

G protein-coupled bile acid receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q35

Chromosome location (bp)

218259496 - 218263859

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000179921 (version 78.38)

Entrez gene

151306

UniProt

Q8TDU6 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8TDU6

Antibodypedia

GPBAR1 antibodies
 

PROTEIN VIEW

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GPBAR1-001
 
GPBAR1-002
 
GPBAR1-003
 
GPBAR1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPBAR1-001 ENSP00000430698
ENST00000479077
Q8TDU6
Show all »
Show » Show » 330 35.2 No 7
GPBAR1-002 ENSP00000430886
ENST00000522678
Q8TDU6
Show all »
Show » Show » 330 35.2 No 7
GPBAR1-003 ENSP00000430202
ENST00000519574
Q8TDU6
Show all »
Show » Show » 330 35.2 No 7
GPBAR1-004 ENSP00000428824
ENST00000521462
Q8TDU6
Show all »
Show » Show » 330 35.2 No 7