DAND5

GENE INFORMATION

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Gene name

DAND5 (HGNC Symbol)

Synonyms

CER2, CKTSF1B3, DANTE, DTE, FLJ38607, GREM3

Description

DAN domain family member 5, BMP antagonist (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.13

Chromosome location (bp)

12965159 - 12974762

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000179284 (version 78.38)

Entrez gene

199699

UniProt

Q8N907 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8N907

Antibodypedia

DAND5 antibodies
 

PROTEIN VIEW

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DAND5-001
 
DAND5-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAND5-001 ENSP00000323155
ENST00000317060
Q8N907
Show all »
Show » Show » 189 20.2 Yes 0
DAND5-002 ENSP00000467806
ENST00000585548
K7EQF6
Show all »
Show » 163 17.4 Yes 0