TOP3A

GENE INFORMATION

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Gene name

TOP3A (HGNC Symbol)

Synonyms

TOP3, ZGRF7

Description

Topoisomerase (DNA) III alpha (HGNC Symbol)

Entrez gene summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

p11.2

Chromosome location (bp)

18271428 - 18315007

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177302 (version 78.38)

Entrez gene

7156

UniProt

Q13472 (UniProt - Evidence at protein level)

neXtProt

NX_Q13472

Antibodypedia

TOP3A antibodies
 

PROTEIN VIEW

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TOP3A-001
 
TOP3A-008
 
TOP3A-020
 
TOP3A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TOP3A-001 ENSP00000321636
ENST00000321105
Q13472
Show all »
Show » Show » 1001 112.4 No 0
TOP3A-008 ENSP00000465864
ENST00000489131
Show » 25 2.8 No 0
TOP3A-020 ENSP00000462790
ENST00000580095
Q13472
Show all »
Show » Show » 976 109.3 No 0
TOP3A-201 ENSP00000442336
ENST00000542570
Q13472
Show all »
Show » Show » 1001 112.4 No 0