POLE

GENE INFORMATION

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Gene name

POLE (HGNC Symbol)

Synonyms

POLE1

Description

Polymerase (DNA directed), epsilon, catalytic subunit (HGNC Symbol)

Entrez gene summary

This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]

Chromosome

12

Cytoband

q24.33

Chromosome location (bp)

132623753 - 132687365

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177084 (version 78.38)

Entrez gene

5426

UniProt

Q07864 (UniProt - Evidence at protein level)

neXtProt

NX_Q07864

Antibodypedia

POLE antibodies
 

PROTEIN VIEW

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POLE-001
 
POLE-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

POLE-001 ENSP00000322570
ENST00000320574
Q07864
Show all »
Show » Show » 2286 261.5 No 0
POLE-004 ENSP00000445753
ENST00000535270
F5H1D6
Show all »
Show » Show » 2259 258.4 No 0