ANAPC2

GENE INFORMATION

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Gene name

ANAPC2 (HGNC Symbol)

Synonyms

APC2, KIAA1406

Description

Anaphase promoting complex subunit 2 (HGNC Symbol)

Entrez gene summary

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.3

Chromosome location (bp)

137174784 - 137188549

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000176248 (version 78.38)

Entrez gene

29882

UniProt

Q9UJX6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UJX6

Antibodypedia

ANAPC2 antibodies
 

PROTEIN VIEW

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ANAPC2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANAPC2-001 ENSP00000314004
ENST00000323927
Q9UJX6
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