DDIT3

GENERAL INFORMATION

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Gene name

DDIT3

Gene description

DNA-damage-inducible transcript 3

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues showed weak to moderate cytoplasmic and/or nuclear/nucleolar positivity, with additional membranous staining in few cases. Neuropil and subset of glial cells were distinctly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA068416
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

DDIT3 (HGNC Symbol)

Synonyms

CHOP, CHOP10, GADD153

Description

DNA-damage-inducible transcript 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

Chromosome

12

Cytoband

q13.3

Chromosome location (bp)

57516588 - 57520517

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175197 (version 78.38)

Entrez gene

1649

UniProt

P35638 (UniProt - Evidence at protein level)

neXtProt

NX_P35638

Antibodypedia

DDIT3 antibodies


PROTEIN BROWSER

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ENST00000346473
 
ENST00000547303
 
ENST00000547526
 
ENST00000551116
 
ENST00000552740
 
ENST00000618206
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DDIT3-001 ENSP00000340671
ENST00000346473
P35638
Show all »
Show » Show » 169 19.2 No 0
DDIT3-002 ENSP00000448665
ENST00000551116
P35638
Show all »
Show » Show » 192 21.7 No 0
DDIT3-004 ENSP00000447503
ENST00000547526
F8W133
Show all »
Show » 145 16 No 0
DDIT3-005 ENSP00000447803
ENST00000552740
P35638
Show all »
Show » Show » 192 21.7 No 0
DDIT3-006 ENSP00000447188
ENST00000547303
P35638
Show all »
Show » Show » 169 19.2 No 0
DDIT3-201 ENSP00000481270
ENST00000618206
P35638
Show all »
Show » Show » 168 19.1 No 0