MRPS22

GENE INFORMATION

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Gene name

MRPS22 (HGNC Symbol)

Synonyms

C3orf5, GIBT, GK002, MRP-S22

Description

Mitochondrial ribosomal protein S22 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q23

Chromosome location (bp)

139005806 - 139357223

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175110 (version 78.38)

Entrez gene

56945

UniProt

P82650 (UniProt - Evidence at protein level)

neXtProt

NX_P82650

Antibodypedia

MRPS22 antibodies
 

PROTEIN VIEW

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MRPS22-001
 
MRPS22-005
 
MRPS22-007
 
MRPS22-008
 
MRPS22-012
 
MRPS22-014
 
MRPS22-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPS22-001 ENSP00000418008
ENST00000495075
P82650
Show all »
Show » Show » 360 41.3 Yes 0
MRPS22-005 ENSP00000418233
ENST00000465056
G5E9V5
Show all »
Show » Show » 359 41.2 Yes 0
MRPS22-007 ENSP00000419303
ENST00000478464
G5E9W7
Show all »
Show » Show » 319 36.8 No 0
MRPS22-008 ENSP00000419920
ENST00000465373
H7C5H3
Show all »
Show » Show » 200 22.8 No 0
MRPS22-012 ENSP00000420229
ENST00000480644
Show » 121 14.6 No 0
MRPS22-014 ENSP00000417104
ENST00000495225
C9J5D8
Show all »
Show » 51 5.6 No 0
MRPS22-201 ENSP00000310785
ENST00000310776
P82650
Show all »
Show » Show » 360 41.3 Yes 0