FZD4

GENERAL INFORMATION

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Gene name

FZD4

Gene description

Frizzled class receptor 4

Protein class

CD markers
Disease related genes
G-protein coupled receptors
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (adipose tissue)
GTEx:Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein localization

Most normal cells showed weak to moderate cytoplasmic and/or nuclear staining. Squamous epithelia and exocrine pancreas were strongly stained. Islets of Langerhans, urothelial cells, spleen, glial cells, smooth and skeletal muscle cells were mostly negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA042328
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (adipose tissue)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (adipose tissue)

Organ

Expression



GENE INFORMATION

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Gene name

FZD4 (HGNC Symbol)

Synonyms

CD344, EVR1

Description

Frizzled class receptor 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q14.2

Chromosome location (bp)

86945679 - 86955391

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174804 (version 78.38)

Entrez gene

8322

UniProt

Q9ULV1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9ULV1

Antibodypedia

FZD4 antibodies


PROTEIN BROWSER

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ENST00000531380
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FZD4-001 ENSP00000434034
ENST00000531380
Q9ULV1
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