SRP72

GENE INFORMATION

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Gene name

SRP72

Synonyms

Description

Signal recognition particle 72kDa (HGNC Symbol)

Entrez gene summary

This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Chromosome

4

Cytoband

q12

Chromosome location (bp)

56466915 - 56503680

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174780 (version 78.38)

Entrez gene

6731

UniProt

O76094 (UniProt - Evidence at protein level)

neXtProt

NX_O76094

Antibodypedia

SRP72 antibodies
 

PROTEIN VIEW

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SRP72-001
 
SRP72-002
 
SRP72-005
 
SRP72-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SRP72-001 ENSP00000342181
ENST00000342756
O76094
Show all »
Show » Show » 671 74.6 No 0
SRP72-002 ENSP00000425190
ENST00000505314
Show » Show » 357 39.6 No 0
SRP72-005 ENSP00000424576
ENST00000510663
O76094
Show all »
Show » Show » 610 67.9 No 0
SRP72-008 ENSP00000473576
ENST00000504757
R4GNC1
Show all »
Show » Show » 220 24.8 No 0