LIG4

GENERAL INFORMATION

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Gene name

LIG4

Gene description

Ligase IV, DNA, ATP-dependent

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Mainly nuclear expression in all tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA001334
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

LIG4

Synonyms

Description

Ligase IV, DNA, ATP-dependent (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q33.3

Chromosome location (bp)

108207439 - 108218368

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174405 (version 78.38)

Entrez gene

3981

UniProt

P49917 (UniProt - Evidence at protein level)

neXtProt

NX_P49917

Antibodypedia

LIG4 antibodies


PROTEIN BROWSER

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ENST00000356922
 
ENST00000405925
 
ENST00000442234
 
ENST00000611712
 
ENST00000614526
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LIG4-001 ENSP00000484288
ENST00000611712
P49917
Show all »
Show » Show » 911 104 No 0
LIG4-002 ENSP00000385955
ENST00000405925
P49917
Show all »
Show » Show » 911 104 No 0
LIG4-003 ENSP00000402030
ENST00000442234
P49917
Show all »
Show » Show » 911 104 No 0
LIG4-004 ENSP00000480814
ENST00000614526
P49917
Show all »
Show » Show » 844 96.2 No 0
LIG4-201 ENSP00000349393
ENST00000356922
P49917
Show all »
Show » Show » 911 104 No 0