UGT2A1

GENE INFORMATION

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Gene name

UGT2A1

Synonyms

Description

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the UDP-glycosyltransferase family, members of which catalyze biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. [provided by RefSeq, Jul 2014]

Chromosome

4

Cytoband

q13.3

Chromosome location (bp)

69588417 - 69653249

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173610 (version 78.38)

Entrez gene

10941

UniProt

Q9Y4X1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y4X1

Antibodypedia

UGT2A1 antibodies
 

PROTEIN VIEW

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UGT2A1-001
 
UGT2A1-002
 
UGT2A1-004
 
UGT2A1-005
 
UGT2A1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UGT2A1-001 ENSP00000424478
ENST00000503640
Q9Y4X1
Show all »
Show » Show » 527 59.9 Yes 1
UGT2A1-002 ENSP00000421432
ENST00000512704
Show » Show » 483 55.2 Yes 1
UGT2A1-004 ENSP00000286604
ENST00000286604
Q9Y4X1
Show all »
Show » Show » 527 60 Yes 1
UGT2A1-005 ENSP00000427709
ENST00000505512
Show » Show » 158 17.9 Yes 0
UGT2A1-201 ENSP00000387888
ENST00000457664
Q9Y4X1
Show all »
Show » Show » 527 59.9 Yes 1