GLRX

GENE INFORMATION

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Gene name

GLRX (HGNC Symbol)

Synonyms

GRX, GRX1

Description

Glutaredoxin (thioltransferase) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]

Chromosome

5

Cytoband

q15

Chromosome location (bp)

95751319 - 95823005

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173221 (version 78.38)

Entrez gene

2745

UniProt

P35754 (UniProt - Evidence at protein level)

neXtProt

NX_P35754

Antibodypedia

GLRX antibodies
 

PROTEIN VIEW

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GLRX-001
 
GLRX-002
 
GLRX-004
 
GLRX-005
 
GLRX-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLRX-001 ENSP00000237858
ENST00000237858
P35754
Show all »
Show » Show » 106 11.8 No 0
GLRX-002 ENSP00000369314
ENST00000379979
P35754
Show all »
Show » Show » 106 11.8 No 0
GLRX-004 ENSP00000427353
ENST00000505427
P35754
Show all »
Show » Show » 106 11.8 No 0
GLRX-005 ENSP00000424636
ENST00000512469
P35754
Show all »
Show » Show » 106 11.8 No 0
GLRX-007 ENSP00000422708
ENST00000508780
P35754
Show all »
Show » Show » 106 11.8 No 0