RELA

GENERAL INFORMATION

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Gene name

RELA

Gene description

V-rel avian reticuloendotheliosis viral oncogene homolog A

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
RAS pathway related proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

13
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression of varying intensity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
CAB004264 , CAB005030
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

RELA (HGNC Symbol)

Synonyms

NFKB3, p65

Description

V-rel avian reticuloendotheliosis viral oncogene homolog A (HGNC Symbol)

Entrez gene summary

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

65653596 - 65663094

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173039 (version 78.38)

Entrez gene

5970

UniProt

Q04206 (UniProt - Evidence at protein level)

neXtProt

NX_Q04206

Antibodypedia

RELA antibodies


PROTEIN BROWSER

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ENST00000308639
 
ENST00000406246
 
ENST00000525693
 
ENST00000526257
 
ENST00000527749
 
ENST00000527874
 
ENST00000532879
 
ENST00000532999
 
ENST00000533187
 
ENST00000534283
 
ENST00000534558
 
ENST00000612991
 
ENST00000615805
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RELA-001 ENSP00000384273
ENST00000406246
Q04206
Show all »
Show » Show » 551 60.2 No 0
RELA-002 ENSP00000311508
ENST00000308639
Q04206
Show all »
Show » Show » 548 59.9 No 0
RELA-004 ENSP00000433526
ENST00000532999
E9PKH5
Show all »
Show » Show » 418 46.7 No 0
RELA-006 ENSP00000432537
ENST00000525693
Q2TAM5
Show all »
Show » Show » 377 42.9 No 0
RELA-007 ENSP00000431304
ENST00000526257
Show » Show » 72 8.3 No 0
RELA-013 ENSP00000434098
ENST00000533187
E9PRX2
Show all »
Show » Show » 95 10.7 No 0
RELA-014 ENSP00000436545
ENST00000527749
E9PI38
Show all »
Show » Show » 185 20.8 No 0
RELA-015 ENSP00000433616
ENST00000534283
E9PJZ9
Show all »
Show » Show » 29 3.3 No 0
RELA-016 ENSP00000435531
ENST00000527874
E9PJR1
Show all »
Show » Show » 90 10.1 No 0
RELA-022 ENSP00000434372
ENST00000534558
E9PQS6
Show all »
Show » Show » 208 23.4 No 0
RELA-027 ENSP00000431153
ENST00000532879
E9PMD5
Show all »
Show » Show » 161 17.9 No 0
RELA-201 ENSP00000483705
ENST00000612991
Q96F54
Show all »
Show » Show » 448 49.6 No 0
RELA-202 ENSP00000479572
ENST00000615805
Q96F54
Show all »
Show » Show » 246 27.7 No 0