CES2

GENERAL INFORMATION

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Gene name

CES2

Gene description

Carboxylesterase 2

Protein class

Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Granular cytoplasmic expression in several tissues, highly abundant in liver, renal tubules and gastrointestinal mucosa.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA018897
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CES2 (HGNC Symbol)

Synonyms

CE-2, CES2A1, iCE

Description

Carboxylesterase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

Chromosome

16

Cytoband

q22.1

Chromosome location (bp)

66934444 - 66945096

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172831 (version 78.38)

Entrez gene

8824

UniProt

O00748 (UniProt - Evidence at protein level)

neXtProt

NX_O00748

Antibodypedia

CES2 antibodies


PROTEIN BROWSER

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ENST00000317091
 
ENST00000417689
 
ENST00000561697
 
ENST00000564420
 
ENST00000566182
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CES2-001 ENSP00000317842
ENST00000317091
A0A024R6X1
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Show » Show » 623 68.9 No 1
CES2-003 ENSP00000394452
ENST00000417689
O00748
Show all »
Show » Show » 607 67.1 No 1
CES2-005 ENSP00000463641
ENST00000561697
J3QLP1
Show all »
Show » 125 13.7 No 0
CES2-010 ENSP00000464620
ENST00000564420
Show » 201 23 No 0
CES2-012 ENSP00000463166
ENST00000566182
J3QKN7
Show all »
Show » 22 2.4 No 0