MAL

GENE INFORMATION

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Gene name

MAL

Synonyms

Description

Mal, T-cell differentiation protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]

Chromosome

2

Cytoband

q11.1

Chromosome location (bp)

95025677 - 95053996

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172005 (version 78.38)

Entrez gene

4118

UniProt

P21145 (UniProt - Evidence at protein level)

neXtProt

NX_P21145

Antibodypedia

MAL antibodies
 

PROTEIN VIEW

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MAL-001
 
MAL-002
 
MAL-003
 
MAL-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAL-001 ENSP00000310880
ENST00000309988
P21145
Show all »
Show » Show » 153 16.7 No 4
MAL-002 ENSP00000306568
ENST00000353004
P21145
Show all »
Show » Show » 111 12.1 No 3
MAL-003 ENSP00000304924
ENST00000354078
P21145
Show all »
Show » Show » 97 10.6 No 2
MAL-004 ENSP00000322860
ENST00000349807
P21145
Show all »
Show » Show » 55 6 No 1