STAT2

GENE INFORMATION

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Gene name

STAT2 (HGNC Symbol)

Synonyms

STAT113

Description

Signal transducer and activator of transcription 2, 113kDa (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Chromosome

12

Cytoband

q13.3

Chromosome location (bp)

56341597 - 56360155

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170581 (version 78.38)

Entrez gene

6773

UniProt

P52630 (UniProt - Evidence at protein level)

neXtProt

NX_P52630

Antibodypedia

STAT2 antibodies
 

PROTEIN VIEW

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STAT2-001
 
STAT2-002
 
STAT2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STAT2-001 ENSP00000450751
ENST00000557235
P52630
Show all »
Show » Show » 847 97.5 No 0
STAT2-002 ENSP00000315768
ENST00000314128
P52630
Show all »
Show » Show » 851 97.9 No 0
STAT2-004 ENSP00000387354
ENST00000418572
B4DLC8
Show all »
Show » Show » 460 53 No 0