TMED10

GENERAL INFORMATION

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Gene name

TMED10

Gene description

Transmembrane emp24-like trafficking protein 10 (yeast)

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 4 antibodies.
HPA047139 , HPA050539 , CAB034442 , CAB037251
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TMED10 (HGNC Symbol)

Synonyms

P24(DELTA), TMP21

Description

Transmembrane emp24-like trafficking protein 10 (yeast) (HGNC Symbol)

Entrez gene summary

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q24.3

Chromosome location (bp)

75131470 - 75176631

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170348 (version 78.38)

Entrez gene

10972

UniProt

P49755 (UniProt - Evidence at protein level)

neXtProt

NX_P49755

Antibodypedia

TMED10 antibodies


PROTEIN BROWSER

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ENST00000303575
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TMED10-001 ENSP00000303145
ENST00000303575
P49755
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