CTNND2

GENE INFORMATION

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Gene name

CTNND2 (HGNC Symbol)

Synonyms

GT24, NPRAP

Description

Catenin (cadherin-associated protein), delta 2 (HGNC Symbol)

Entrez gene summary

This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

Chromosome

5

Cytoband

p15.2

Chromosome location (bp)

10971840 - 11904043

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169862 (version 78.38)

Entrez gene

1501

UniProt

Q9UQB3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UQB3

Antibodypedia

CTNND2 antibodies
 

PROTEIN VIEW

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CTNND2-001
 
CTNND2-004
 
CTNND2-005
 
CTNND2-008
 
CTNND2-009
 
CTNND2-012
 
CTNND2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTNND2-001 ENSP00000307134
ENST00000304623
Q9UQB3
Show all »
Show » Show » 1225 132.7 No 0
CTNND2-004 ENSP00000426887
ENST00000503622
B4DRK2
Show all »
Show » Show » 888 98 No 0
CTNND2-005 ENSP00000426510
ENST00000511377
E7EPC8
Show all »
Show » Show » 1134 123.1 No 0
CTNND2-008 ENSP00000424296
ENST00000508761
D6RBA8
Show all »
Show » Show » 169 18.4 No 0
CTNND2-009 ENSP00000422389
ENST00000502551
D6RC65
Show all »
Show » Show » 209 22.7 No 0
CTNND2-012 ENSP00000426625
ENST00000513598
D6RF55
Show all »
Show » Show » 181 18.9 No 0
CTNND2-201 ENSP00000391155
ENST00000458100
Show » Show » 320 35.8 No 0