PCBP1

GENE INFORMATION

? »

Gene name

PCBP1 (HGNC Symbol)

Synonyms

hnRNP-E1, hnRNP-X, HNRPE1, HNRPX

Description

Poly(rC) binding protein 1 (HGNC Symbol)

Entrez gene summary

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p13.3

Chromosome location (bp)

70087454 - 70089203

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169564 (version 78.38)

Entrez gene

5093

UniProt

Q15365 (UniProt - Evidence at protein level)

neXtProt

NX_Q15365

Antibodypedia

PCBP1 antibodies
 

PROTEIN VIEW

? »
 
 
 
PCBP1-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCBP1-001 ENSP00000305556
ENST00000303577
Q15365
Show all »
Show » Show » 356 37.5 No 0