RASSF6

GENERAL INFORMATION

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Gene name

RASSF6

Gene description

Ras association (RalGDS/AF-6) domain family member 6

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (stomach)
GTEx:Tissue enhanced (stomach)

Protein evidence

Evidence at protein level

Protein localization

Smooth muscle showed strong cytoplasmic positivity. Moderate cytoplasmic and in a few cases nuclear positivity was observed in superficial cells of most squamous epithelia. Myoepithelial cells were distinctly stained. Remaining normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA037711
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (stomach)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (stomach)

Organ

Expression



GENE INFORMATION

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Gene name

RASSF6

Synonyms

Description

Ras association (RalGDS/AF-6) domain family member 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

Chromosome

4

Cytoband

q13.3

Chromosome location (bp)

73571550 - 73620631

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169435 (version 78.38)

Entrez gene

166824

UniProt

Q6ZTQ3 (UniProt - Evidence at protein level)

neXtProt

NX_Q6ZTQ3

Antibodypedia

RASSF6 antibodies


PROTEIN BROWSER

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ENST00000307439
 
ENST00000335049
 
ENST00000342081
 
ENST00000395777
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RASSF6-001 ENSP00000303877
ENST00000307439
Q6ZTQ3
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Show » Show » 337 39.8 No 0
RASSF6-002 ENSP00000340578
ENST00000342081
Q6ZTQ3
Show all »
Show » Show » 369 43.4 No 0
RASSF6-003 ENSP00000335582
ENST00000335049
Q6ZTQ3
Show all »
Show » Show » 325 37.9 No 0
RASSF6-004 ENSP00000379123
ENST00000395777
Q6ZTQ3
Show all »
Show » Show » 303 35.8 No 0