Tissue expression of PTK2 - Summary - The Human Protein Atlas

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PTK2

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	PTK2
Gene description	Protein tyrosine kinase 2
Protein class	Cancer-related genes Cytoskeleton related proteins Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	33
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 2 antibodies. HPA001842 , CAB004036
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	PTK2 (HGNC Symbol)
Synonyms	FADK, FAK, FAK1, PPP1R71
Description	Protein tyrosine kinase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	140657900 - 141002216
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169398 (version 78.38)
Entrez gene	5747
UniProt	Q05397 (UniProt - Evidence at protein level)
neXtProt	NX_Q05397
Antibodypedia	PTK2 antibodies

PROTEIN BROWSER

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ENST00000340930		ENST00000395218		ENST00000430260		ENST00000517453		ENST00000517712		ENST00000517887		ENST00000519024		ENST00000519419		ENST00000519465		ENST00000519654		ENST00000519881		ENST00000520045		ENST00000520151		ENST00000520475		ENST00000520828		ENST00000520892		ENST00000521059		ENST00000521332		ENST00000521395		ENST00000521562		ENST00000521907		ENST00000521986		ENST00000522424		ENST00000522684		ENST00000522950		ENST00000523388		ENST00000523435		ENST00000523539		ENST00000523679		ENST00000523803		ENST00000524040		ENST00000524257		ENST00000524357

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
PTK2-001	ENSP00000429911 ENST00000522684	Q05397 Show all » « Hide Q05397 [Direct mapping] Focal adhesion kinase 1 B4DWJ1 [Target identity:34%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000403416}; cDNA FLJ57218, highly similar to Focal adhesion kinase 1 {ECO:0000313\|EMBL:BAG63053.1} E5RGA6 [Target identity:14%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428792} E5RG80 [Target identity:12%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427774} E5RJQ2 [Target identity:12%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000431106} E5RFW9 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427904} E5RG66 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RH01 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RI72 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429530} E5RH48 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RHD8 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916} E5RHK7 [Target identity:6%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702} E5RIK4 [Target identity:6%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RG86 [Target identity:5%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427762} E5RH08 [Target identity:4%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Cytoskeleton related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0001725 [stress fiber] GO:0001890 [placenta development] GO:0001934 [positive regulation of protein phosphorylation] GO:0003007 [heart morphogenesis] GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0008432 [JUN kinase binding] GO:0009790 [embryo development] GO:0010594 [regulation of endothelial cell migration] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019901 [protein kinase binding] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030010 [establishment of cell polarity] GO:0030168 [platelet activation] GO:0030335 [positive regulation of cell migration] GO:0032319 [regulation of Rho GTPase activity] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0038007 [netrin-activated signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0045087 [innate immune response] GO:0045667 [regulation of osteoblast differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0048870 [cell motility] GO:0051493 [regulation of cytoskeleton organization] GO:0051893 [regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060396 [growth hormone receptor signaling pathway] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000811 [negative regulation of anoikis]	1052	119.2	No
PTK2-002	ENSP00000428492 ENST00000523539	H0YB16 Show all » « Hide H0YB16 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428492} Q8N9D7 [Target identity:99%; Query identity:100%] cDNA FLJ37680 fis, clone BRHIP2012923, highly similar to FOCAL ADHESION KINASE 1 {ECO:0000313\|EMBL:BAC04470.1} B4DWJ1 [Target identity:50%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000403416}; cDNA FLJ57218, highly similar to Focal adhesion kinase 1 {ECO:0000313\|EMBL:BAG63053.1} E5RG80 [Target identity:18%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427774} E5RJQ2 [Target identity:18%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000431106} E5RHD8 [Target identity:15%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916} E5RHK7 [Target identity:9%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005524 [ATP binding] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation]	724	81.5	No
PTK2-004	ENSP00000430916 ENST00000517712	E5RHD8 Show all » « Hide E5RHD8 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004713 [protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0018108 [peptidyl-tyrosine phosphorylation]	115	12.9	No
PTK2-005	ENSP00000429170 ENST00000519465	E9PEI4 Show all » « Hide E9PEI4 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429170} B4DWJ1 [Target identity:53%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000403416}; cDNA FLJ57218, highly similar to Focal adhesion kinase 1 {ECO:0000313\|EMBL:BAG63053.1} E5RG80 [Target identity:19%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427774} E5RJQ2 [Target identity:19%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000431106} E5RHD8 [Target identity:16%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916} E5RIR5 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428380} E5RHK7 [Target identity:9%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005524 [ATP binding] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation]	680	76.8	No
PTK2-006	ENSP00000403416 ENST00000430260	B4DWJ1 Show all » « Hide B4DWJ1 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000403416}; cDNA FLJ57218, highly similar to Focal adhesion kinase 1 {ECO:0000313\|EMBL:BAG63053.1} E5RG80 [Target identity:36%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427774} E5RJQ2 [Target identity:36%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000431106} E5RHD8 [Target identity:31%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916} E5RHK7 [Target identity:18%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004713 [protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0018108 [peptidyl-tyrosine phosphorylation]	362	40.2	No
PTK2-007	ENSP00000429129 ENST00000519419	E7ESA6 Show all » « Hide E7ESA6 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429129} B4DWJ1 [Target identity:33%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000403416}; cDNA FLJ57218, highly similar to Focal adhesion kinase 1 {ECO:0000313\|EMBL:BAG63053.1} E5RGA6 [Target identity:14%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428792} E5RG80 [Target identity:12%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427774} E5RJQ2 [Target identity:12%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000431106} E5RFW9 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427904} E5RG66 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RH01 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RHD8 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916} E5RI72 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429530} E5RH48 [Target identity:9%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RHK7 [Target identity:6%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702} E5RG86 [Target identity:5%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427762} E5RIK4 [Target identity:5%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:4%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0001725 [stress fiber] GO:0001890 [placenta development] GO:0001934 [positive regulation of protein phosphorylation] GO:0003007 [heart morphogenesis] GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0008432 [JUN kinase binding] GO:0009790 [embryo development] GO:0010594 [regulation of endothelial cell migration] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019901 [protein kinase binding] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030010 [establishment of cell polarity] GO:0030168 [platelet activation] GO:0030335 [positive regulation of cell migration] GO:0032319 [regulation of Rho GTPase activity] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0038007 [netrin-activated signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0045087 [innate immune response] GO:0045667 [regulation of osteoblast differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0048870 [cell motility] GO:0051493 [regulation of cytoskeleton organization] GO:0051893 [regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060396 [growth hormone receptor signaling pathway] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000811 [negative regulation of anoikis]	1096	124.1	No
PTK2-008	ENSP00000429082 ENST00000517887	E7ESA6 Show all » « Hide E7ESA6 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429129} B4DWJ1 [Target identity:33%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000403416}; cDNA FLJ57218, highly similar to Focal adhesion kinase 1 {ECO:0000313\|EMBL:BAG63053.1} E5RGA6 [Target identity:14%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428792} E5RG80 [Target identity:12%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427774} E5RJQ2 [Target identity:12%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000431106} E5RFW9 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427904} E5RG66 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RH01 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RHD8 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916} E5RI72 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429530} E5RH48 [Target identity:9%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RHK7 [Target identity:6%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702} E5RG86 [Target identity:5%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427762} E5RIK4 [Target identity:5%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:4%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0001725 [stress fiber] GO:0001890 [placenta development] GO:0001934 [positive regulation of protein phosphorylation] GO:0003007 [heart morphogenesis] GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0008432 [JUN kinase binding] GO:0009790 [embryo development] GO:0010594 [regulation of endothelial cell migration] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019901 [protein kinase binding] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030010 [establishment of cell polarity] GO:0030168 [platelet activation] GO:0030335 [positive regulation of cell migration] GO:0032319 [regulation of Rho GTPase activity] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0038007 [netrin-activated signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0045087 [innate immune response] GO:0045667 [regulation of osteoblast differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0048870 [cell motility] GO:0051493 [regulation of cytoskeleton organization] GO:0051893 [regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060396 [growth hormone receptor signaling pathway] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000811 [negative regulation of anoikis]	1096	124.1	No
PTK2-009	ENSP00000430603 ENST00000521986	H0YBZ1 Show all » « Hide H0YBZ1 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430603} B4DH13 [Target identity:99%; Query identity:100%] cDNA FLJ57973, highly similar to Focal adhesion kinase 1 {ECO:0000313\|EMBL:BAG57974.1} E5RG80 [Target identity:17%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427774} E5RJQ2 [Target identity:17%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000431106} E5RHD8 [Target identity:15%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916} E5RHK7 [Target identity:8%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005524 [ATP binding] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation]	753	84.8	No
PTK2-010	ENSP00000429929 ENST00000519654	Q8IYN9 Show all » « Hide Q8IYN9 [Target identity:98%; Query identity:100%] PTK2 protein {ECO:0000313\|EMBL:AAH35404.1} E5RGA6 [Target identity:15%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428792} E5RFW9 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427904} E5RG66 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RH01 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RHD8 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916} E5RI72 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429530} E5RH48 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RIK4 [Target identity:6%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RG86 [Target identity:5%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427762} E5RH08 [Target identity:5%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005524 [ATP binding] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation]	1017	115.4	No
PTK2-011	ENSP00000341189 ENST00000340930	Q05397 Show all » « Hide Q05397 [Direct mapping] Focal adhesion kinase 1 E5RGA6 [Target identity:14%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428792} E5RG80 [Target identity:12%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427774} E5RJQ2 [Target identity:12%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000431106} E5RFW9 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427904} E5RG66 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RI72 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429530} E5RH01 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RH48 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RHD8 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916} E5RHK7 [Target identity:6%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702} E5RIK4 [Target identity:6%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RG86 [Target identity:5%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427762} E5RH08 [Target identity:4%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Cytoskeleton related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000226 [microtubule cytoskeleton organization] GO:0001525 [angiogenesis] GO:0001568 [blood vessel development] GO:0001570 [vasculogenesis] GO:0001725 [stress fiber] GO:0001764 [neuron migration] GO:0001890 [placenta development] GO:0001934 [positive regulation of protein phosphorylation] GO:0003007 [heart morphogenesis] GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0008432 [JUN kinase binding] GO:0009790 [embryo development] GO:0010594 [regulation of endothelial cell migration] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016324 [apical plasma membrane] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019901 [protein kinase binding] GO:0021955 [central nervous system neuron axonogenesis] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030010 [establishment of cell polarity] GO:0030027 [lamellipodium] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0030335 [positive regulation of cell migration] GO:0032319 [regulation of Rho GTPase activity] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0038007 [netrin-activated signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0040023 [establishment of nucleus localization] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043542 [endothelial cell migration] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0045087 [innate immune response] GO:0045667 [regulation of osteoblast differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0046621 [negative regulation of organ growth] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0048870 [cell motility] GO:0050771 [negative regulation of axonogenesis] GO:0051493 [regulation of cytoskeleton organization] GO:0051893 [regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051964 [negative regulation of synapse assembly] GO:0060396 [growth hormone receptor signaling pathway] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000811 [negative regulation of anoikis]	1065	120.9	No
PTK2-014	ENSP00000429437 ENST00000522950	E5RII9 Show all » « Hide E5RII9 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429437}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		67	7.6	No
PTK2-015	ENSP00000430828 ENST00000523435	E5RI03 Show all » « Hide E5RI03 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430828}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004713 [protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0018108 [peptidyl-tyrosine phosphorylation]	120	13.7	No
PTK2-019	ENSP00000431106 ENST00000521562	E5RJQ2 Show all » « Hide E5RJQ2 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000431106} E5RHK7 [Target identity:50%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		132	14.8	No
PTK2-020	ENSP00000429702 ENST00000523388	E5RHK7 Show all » « Hide E5RHK7 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		67	7.3	No
PTK2-032	ENSP00000429530 ENST00000523803	E5RI72 Show all » « Hide E5RI72 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429530} E5RG66 [Target identity:99%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RH01 [Target identity:97%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RH48 [Target identity:89%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RIK4 [Target identity:54%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:42%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		120	13.7	No
PTK2-033	ENSP00000428792 ENST00000520475	E5RGA6 Show all » « Hide E5RGA6 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428792} E5RFW9 [Target identity:77%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427904} E5RG66 [Target identity:76%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RI72 [Target identity:76%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429530} E5RH01 [Target identity:75%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RH48 [Target identity:68%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RIK4 [Target identity:41%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:32%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005856 [cytoskeleton]	156	18.2	No
PTK2-034	ENSP00000429907 ENST00000521395	E5RH48 Show all » « Hide E5RH48 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RIK4 [Target identity:60%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:47%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		107	12	No
PTK2-035	ENSP00000427795 ENST00000521907	E5RG66 Show all » « Hide E5RG66 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RH01 [Target identity:98%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RH48 [Target identity:89%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RIK4 [Target identity:54%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:42%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		119	13.5	No
PTK2-037	ENSP00000430277 ENST00000519881	E5RFW9 Show all » « Hide E5RFW9 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427904} E5RI72 [Target identity:99%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429530} E5RG66 [Target identity:98%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RH01 [Target identity:96%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RH48 [Target identity:88%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RIK4 [Target identity:53%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:42%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		121	13.8	No
PTK2-038	ENSP00000427904 ENST00000520892	E5RFW9 Show all » « Hide E5RFW9 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427904} E5RI72 [Target identity:99%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429530} E5RG66 [Target identity:98%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RH01 [Target identity:96%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RH48 [Target identity:88%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RIK4 [Target identity:53%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:42%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		121	13.8	No
PTK2-039	ENSP00000429409 ENST00000521332	E5RIK4 Show all » « Hide E5RIK4 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:78%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		65	7.2	No
PTK2-040	ENSP00000429028 ENST00000523679		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		15	1.5	No
PTK2-041	ENSP00000427762 ENST00000520828	E5RG86 Show all » « Hide E5RG86 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427762}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005856 [cytoskeleton]	59	7.2	No
PTK2-042	ENSP00000431023 ENST00000524257		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		8	0.9	No
PTK2-043	ENSP00000430951 ENST00000517453	E5RH01 Show all » « Hide E5RH01 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RH48 [Target identity:91%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RIK4 [Target identity:55%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:43%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		117	13.2	No
PTK2-044	ENSP00000430044 ENST00000520045	E5RH01 Show all » « Hide E5RH01 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RH48 [Target identity:91%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RIK4 [Target identity:55%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:43%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		117	13.2	No
PTK2-045	ENSP00000430037 ENST00000524040	E5RH08 Show all » « Hide E5RH08 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		51	5.6	No
PTK2-047	ENSP00000427774 ENST00000522424	E5RG80 Show all » « Hide E5RG80 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427774} E5RJQ2 [Target identity:99%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000431106} E5RHK7 [Target identity:50%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		133	15	No
PTK2-053	ENSP00000428232 ENST00000519024	E5RJI4 Show all » « Hide E5RJI4 [Target identity:99%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428232}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	169	19.3	No
PTK2-054	ENSP00000428482 ENST00000520151	E5RI29 Show all » « Hide E5RI29 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428482} E5RIR5 [Target identity:58%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428380}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	124	14	No
PTK2-055	ENSP00000429001 ENST00000524357	E5RJP0 Show all » « Hide E5RJP0 [Target identity:100%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429001} E5RIK4 [Target identity:53%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RH08 [Target identity:41%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		122	13.8	No
PTK2-057	ENSP00000429474 ENST00000521059	Q05397 Show all » « Hide Q05397 [Direct mapping] Focal adhesion kinase 1 B4DWJ1 [Target identity:34%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000403416}; cDNA FLJ57218, highly similar to Focal adhesion kinase 1 {ECO:0000313\|EMBL:BAG63053.1} E5RGA6 [Target identity:14%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428792} E5RG80 [Target identity:12%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427774} E5RJQ2 [Target identity:12%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000431106} E5RFW9 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427904} E5RG66 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RH01 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RI72 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429530} E5RH48 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RHD8 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916} E5RHK7 [Target identity:6%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429702} E5RIK4 [Target identity:6%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RG86 [Target identity:5%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427762} E5RH08 [Target identity:4%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Cytoskeleton related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0001725 [stress fiber] GO:0001890 [placenta development] GO:0001934 [positive regulation of protein phosphorylation] GO:0003007 [heart morphogenesis] GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0008432 [JUN kinase binding] GO:0009790 [embryo development] GO:0010594 [regulation of endothelial cell migration] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019901 [protein kinase binding] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030010 [establishment of cell polarity] GO:0030168 [platelet activation] GO:0030335 [positive regulation of cell migration] GO:0032319 [regulation of Rho GTPase activity] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0038007 [netrin-activated signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0045087 [innate immune response] GO:0045667 [regulation of osteoblast differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0048870 [cell motility] GO:0051493 [regulation of cytoskeleton organization] GO:0051893 [regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060396 [growth hormone receptor signaling pathway] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000811 [negative regulation of anoikis]	1052	119.2	No
PTK2-201	ENSP00000378644 ENST00000395218	Q8IYN9 Show all » « Hide Q8IYN9 [Target identity:100%; Query identity:100%] PTK2 protein {ECO:0000313\|EMBL:AAH35404.1} E5RGA6 [Target identity:15%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000428792} E5RFW9 [Target identity:12%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427904} E5RG66 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427795} E5RH01 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430044} E5RHD8 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430916} E5RI72 [Target identity:11%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429530} E5RH48 [Target identity:10%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429907} E5RIK4 [Target identity:6%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000429409} E5RG86 [Target identity:5%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000427762} E5RH08 [Target identity:5%; Query identity:100%] Focal adhesion kinase 1 {ECO:0000313\|Ensembl:ENSP00000430037}	Show » « Hide Predicted intracellular proteins Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005524 [ATP binding] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0018108 [peptidyl-tyrosine phosphorylation]	1006	114.3	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx