RSPO1

GENE INFORMATION

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Gene name

RSPO1 (HGNC Symbol)

Synonyms

FLJ40906, RSPONDIN

Description

R-spondin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Chromosome

1

Cytoband

p34.3

Chromosome location (bp)

37611350 - 37634923

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169218 (version 78.38)

Entrez gene

284654

UniProt

Q2MKA7 (UniProt - Evidence at protein level)

neXtProt

NX_Q2MKA7

Antibodypedia

RSPO1 antibodies
 

PROTEIN VIEW

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RSPO1-001
 
RSPO1-002
 
RSPO1-003
 
RSPO1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RSPO1-001 ENSP00000481178
ENST00000615459
Q2MKA7
Show all »
Show » Show » 236 26 No 0
RSPO1-002 ENSP00000383846
ENST00000401068
Q2MKA7
Show all »
Show » Show » 263 29 Yes 0
RSPO1-003 ENSP00000348944
ENST00000356545
Q2MKA7
Show all »
Show » Show » 263 29 Yes 0
RSPO1-004 ENSP00000479832
ENST00000612451
Q2MKA7
Show all »
Show » Show » 200 21.8 Yes 0