NPNT - Gene info - The Human Protein Atlas

Gene name

NPNT (HGNC Symbol)

Synonyms

EGFL6L, POEM

Description

Nephronectin (HGNC Symbol)

Entrez gene summary

Chromosome

Cytoband

q24

Chromosome location (bp)

105894775 - 106004027

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168743 (version 78.38)

Entrez gene

255743

UniProt

Q6UXI9 (UniProt - Evidence at transcript level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NPNT-001

ENSP00000369323
ENST00000379987

Q6UXI9
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Q6UXI9 [Direct mapping]
Nephronectin
D6RE63 [Target identity:10%; Query identity:100%]
Nephronectin {ECO:0000313|Ensembl:ENSP00000426951}

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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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565

61.9

Yes

NPNT-002

ENSP00000402884
ENST00000453617

Q6UXI9
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Q6UXI9 [Direct mapping]
Nephronectin
D6RE63 [Target identity:10%; Query identity:100%]
Nephronectin {ECO:0000313|Ensembl:ENSP00000426951}

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582

Yes

NPNT-003

ENSP00000389252
ENST00000427316

Q6UXI9
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Q6UXI9 [Direct mapping]
Nephronectin
D6RE63 [Target identity:10%; Query identity:100%]
Nephronectin {ECO:0000313|Ensembl:ENSP00000426951}

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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001657 [ureteric bud development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0007160 [cell-matrix adhesion]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0030485 [smooth muscle contractile fiber]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0031012 [extracellular matrix]
GO:0033631 [cell-cell adhesion mediated by integrin]
GO:0034678 [integrin alpha8-beta1 complex]
GO:0045184 [establishment of protein localization]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0070062 [extracellular vesicular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0097195 [pilomotor reflex]
GO:2000721 [positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation]

595

65.2

Yes

NPNT-004

ENSP00000422044
ENST00000514622

Q6UXI9
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Q6UXI9 [Direct mapping]
Nephronectin
D6RE63 [Target identity:11%; Query identity:100%]
Nephronectin {ECO:0000313|Ensembl:ENSP00000426951}

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536

58.7

Yes

NPNT-005

ENSP00000302557
ENST00000305572

Q6UXI9
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Q6UXI9 [Direct mapping]
Nephronectin
D6RE63 [Target identity:11%; Query identity:100%]
Nephronectin {ECO:0000313|Ensembl:ENSP00000426951}

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509

55.7

Yes

NPNT-006

ENSP00000422474
ENST00000506666

Q6UXI9
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Q6UXI9 [Direct mapping]
Nephronectin
D6RE63 [Target identity:10%; Query identity:100%]
Nephronectin {ECO:0000313|Ensembl:ENSP00000426951}

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566

Yes

NPNT-008

ENSP00000427507
ENST00000514837

D6RE63
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D6RE63 [Target identity:13%; Query identity:100%]
Nephronectin {ECO:0000313|Ensembl:ENSP00000426951}

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SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0016020 [membrane]

453

49.8

NPNT-009

ENSP00000426146
ENST00000503451

D6RH31
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D6RH31 [Target identity:100%; Query identity:100%]
Nephronectin {ECO:0000313|Ensembl:ENSP00000426146}
D6RE63 [Target identity:10%; Query identity:100%]
Nephronectin {ECO:0000313|Ensembl:ENSP00000426951}

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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0016020 [membrane]

609

66.9

Yes

NPNT-010

ENSP00000426951
ENST00000504304

D6RE63
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D6RE63 [Target identity:100%; Query identity:100%]
Nephronectin {ECO:0000313|Ensembl:ENSP00000426951}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

6.6

NPNT-016

ENSP00000421480
ENST00000504787

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

104

12.1

NPNT-017

ENSP00000426219
ENST00000505917

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

2.8

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.