AXIN2

GENERAL INFORMATION

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Gene name

AXIN2

Gene description

Axin 2

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA042344 , CAB012283 , CAB017783
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

AXIN2 (HGNC Symbol)

Synonyms

DKFZp781B0869, MGC126582

Description

Axin 2 (HGNC Symbol)

Entrez gene summary

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q24.1

Chromosome location (bp)

65528563 - 65561647

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168646 (version 78.38)

Entrez gene

8313

UniProt

Q9Y2T1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y2T1

Antibodypedia

AXIN2 antibodies


PROTEIN BROWSER

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ENST00000307078
 
ENST00000375702
 
ENST00000544103
 
ENST00000577278
 
ENST00000580513
 
ENST00000585045
 
ENST00000611991
 
ENST00000618960
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AXIN2-001 ENSP00000302625
ENST00000307078
Q9Y2T1
Show all »
Show » Show » 843 93.6 No 0
AXIN2-004 ENSP00000364854
ENST00000375702
E7ES00
Show all »
Show » Show » 778 86.7 No 0
AXIN2-005 ENSP00000463761
ENST00000580513
J3QQJ3
Show all »
Show » Show » 192 21.6 Yes 0
AXIN2-006 ENSP00000464264
ENST00000577278
J3QRK4
Show all »
Show » Show » 271 30.1 No 0
AXIN2-007 ENSP00000463192
ENST00000585045
J3QQJ3
Show all »
Show » Show » 192 21.6 Yes 0
AXIN2-008 ENSP00000441151
ENST00000544103
F5GX43
Show all »
Show » Show » 151 16.8 Yes 0
AXIN2-201 ENSP00000481191
ENST00000611991
Show » Show » 160 18 Yes 0
AXIN2-202 ENSP00000478916
ENST00000618960
E7ES00
Show all »
Show » Show » 778 86.7 No 0