PTF1A

GENE INFORMATION

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Gene name

PTF1A (HGNC Symbol)

Synonyms

bHLHa29, PTF1-p48

Description

Pancreas specific transcription factor, 1a (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

p12.2

Chromosome location (bp)

23192327 - 23194252

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168267 (version 78.38)

Entrez gene

256297

UniProt

Q7RTS3 (UniProt - Evidence at protein level)

neXtProt

NX_Q7RTS3

Antibodypedia

PTF1A antibodies
 

PROTEIN VIEW

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PTF1A-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTF1A-001 ENSP00000365687
ENST00000376504
Q7RTS3
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