MAP4K2

GENE INFORMATION

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Gene name

MAP4K2 (HGNC Symbol)

Synonyms

BL44, GCK, RAB8IP

Description

Mitogen-activated protein kinase kinase kinase kinase 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

64788818 - 64803241

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168067 (version 78.38)

Entrez gene

5871

UniProt

Q12851 (UniProt - Evidence at protein level)

neXtProt

NX_Q12851

Antibodypedia

MAP4K2 antibodies
 

PROTEIN VIEW

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MAP4K2-001
 
MAP4K2-002
 
MAP4K2-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP4K2-001 ENSP00000294066
ENST00000294066
Q12851
Show all »
Show » Show » 820 91.6 No 0
MAP4K2-002 ENSP00000366567
ENST00000377350
Show » Show » 812 90.8 No 0
MAP4K2-006 ENSP00000403563
ENST00000439069
C9JCU6
Show all »
Show » Show » 307 34.8 No 0