SOST

GENE INFORMATION

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Gene name

SOST (HGNC Symbol)

Synonyms

VBCH

Description

Sclerostin (HGNC Symbol)

Entrez gene summary

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.31

Chromosome location (bp)

43753731 - 43758788

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167941 (version 78.38)

Entrez gene

50964

UniProt

Q9BQB4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BQB4

Antibodypedia

SOST antibodies
 

PROTEIN VIEW

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SOST-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOST-001 ENSP00000301691
ENST00000301691
Q9BQB4
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