UGT1A6

GENE INFORMATION

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Gene name

UGT1A6 (HGNC Symbol)

Synonyms

GNT1, HLUGP, UGT1F

Description

UDP glucuronosyltransferase 1 family, polypeptide A6 (HGNC Symbol)

Entrez gene summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q37.1

Chromosome location (bp)

233691607 - 233773300

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167165 (version 78.38)

Entrez gene

54578

UniProt

P19224 (UniProt - Evidence at protein level)

neXtProt

NX_P19224

Antibodypedia

UGT1A6 antibodies
 

PROTEIN VIEW

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UGT1A6-001
 
UGT1A6-003
 
UGT1A6-005
 
UGT1A6-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UGT1A6-001 ENSP00000303174
ENST00000305139
P19224
Show all »
Show » Show » 532 60.7 No 1
UGT1A6-003 ENSP00000362523
ENST00000373424
P19224
Show all »
Show » Show » 265 29.6 No 1
UGT1A6-005 ENSP00000386107
ENST00000406651
B5MCT4
Show all »
Show » Show » 176 19.4 No 0
UGT1A6-007 ENSP00000389637
ENST00000441351
C9JMY5
Show all »
Show » Show » 189 21.7 No 1