PHB - Gene info - The Human Protein Atlas

Gene name

PHB (HGNC Symbol)

Synonyms

PHB1

Description

Prohibitin (HGNC Symbol)

Entrez gene summary

This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

Cytoband

q21.33

Chromosome location (bp)

49404049 - 49414905

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167085 (version 78.38)

Entrez gene

5245

UniProt

P35232 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PHB-001

ENSP00000300408
ENST00000300408

P35232
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P35232 [Direct mapping]
Prohibitin
A8K401 [Target identity:100%; Query identity:100%]
Prohibitin, isoform CRA_a {ECO:0000313|EMBL:EAW94680.1}; cDNA FLJ78511, highly similar to Homo sapiens prohibitin (PHB), mRNA {ECO:0000313|EMBL:BAF83455.1}; cDNA, FLJ93035, Homo sapiens prohibitin (PHB), mRNA {ECO:0000313|EMBL:BAG35532.1}
C9JW96 [Target identity:90%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000393320}
E9PCW0 [Target identity:78%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000426433}
E7ESE2 [Target identity:74%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000422182}
C9JZ20 [Target identity:73%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000407828}
D6RBK0 [Target identity:45%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000410680}

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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Mitochondrial proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001649 [osteoblast differentiation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0030308 [negative regulation of cell growth]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050847 [progesterone receptor signaling pathway]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070062 [extracellular vesicular exosome]
GO:0071354 [cellular response to interleukin-6]
GO:0071897 [DNA biosynthetic process]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]

272

29.8

Yes

PHB-002

ENSP00000393320
ENST00000419140

C9JW96
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C9JW96 [Target identity:100%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000393320}
E9PCW0 [Target identity:86%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000426433}
E7ESE2 [Target identity:82%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000422182}
C9JZ20 [Target identity:81%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000407828}
D6RBK0 [Target identity:50%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000410680}

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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

246

26.9

Yes

PHB-003

ENSP00000407828
ENST00000446735

C9JZ20
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C9JZ20 [Target identity:100%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000407828}
D6RBK0 [Target identity:61%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000410680}

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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

201

22.3

Yes

PHB-007

ENSP00000410680
ENST00000434917

D6RBK0
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D6RBK0 [Target identity:100%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000410680}

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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

124

13.7

Yes

PHB-009

ENSP00000426433
ENST00000504124

E9PCW0
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E9PCW0 [Target identity:99%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000426433}
C9JZ20 [Target identity:93%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000407828}
E7ESE2 [Target identity:93%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000422182}
D6RBK0 [Target identity:57%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000410680}

Show » « Hide

   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

216

23.8

Yes

PHB-010

ENSP00000422182
ENST00000512041

E7ESE2
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E7ESE2 [Target identity:100%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000422182}
C9JZ20 [Target identity:99%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000407828}
D6RBK0 [Target identity:61%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000410680}

Show » « Hide

   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

202

22.4

Yes

PHB-201

ENSP00000425035
ENST00000511832

P35232
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P35232 [Direct mapping]
Prohibitin
D6RBK0 [Target identity:80%; Query identity:100%]
Prohibitin {ECO:0000313|Ensembl:ENSP00000410680}

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155

Yes

PHB-202

ENSP00000479488
ENST00000614445

P35232
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Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0001649 [osteoblast differentiation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016020 [membrane]
GO:0016575 [histone deacetylation]
GO:0019899 [enzyme binding]
GO:0030308 [negative regulation of cell growth]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050847 [progesterone receptor signaling pathway]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0070062 [extracellular vesicular exosome]
GO:0071354 [cellular response to interleukin-6]
GO:0071897 [DNA biosynthetic process]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]

272

29.8

Yes

PHB-203

ENSP00000484113
ENST00000617874

P35232
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Show » « Hide

272

29.8

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.