TEF

GENE INFORMATION

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Gene name

TEF (HGNC Symbol)

Synonyms

KIAA1655

Description

Thyrotrophic embryonic factor (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

22

Cytoband

q13.2

Chromosome location (bp)

41367333 - 41399326

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167074 (version 78.38)

Entrez gene

7008

UniProt

Q10587 (UniProt - Evidence at protein level)

neXtProt

NX_Q10587

Antibodypedia

TEF antibodies
 

PROTEIN VIEW

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TEF-001
 
TEF-003
 
TEF-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TEF-001 ENSP00000266304
ENST00000266304
Q10587
Show all »
Show » Show » 303 33.2 No 0
TEF-003 ENSP00000385256
ENST00000406644
Q10587
Show all »
Show » Show » 273 30.6 No 0
TEF-004 ENSP00000411170
ENST00000413942
Show » 184 19.9 No 0