DUSP18

GENERAL INFORMATION

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Gene name

DUSP18

Gene description

Dual specificity phosphatase 18

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed moderate nuclear and/or cytoplasmic positivity. Adrenal cortex and renal glomerular cells showed strong nuclear staining. Prostate, pancreas, spleen and glial cells were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB034070
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

DUSP18 (HGNC Symbol)

Synonyms

DUSP20

Description

Dual specificity phosphatase 18 (HGNC Symbol)

Entrez gene summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Chromosome

22

Cytoband

q12.2

Chromosome location (bp)

30652051 - 30667890

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167065 (version 78.38)

Entrez gene

150290

UniProt

Q8NEJ0 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NEJ0

Antibodypedia

DUSP18 antibodies


PROTEIN BROWSER

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ENST00000334679
 
ENST00000342474
 
ENST00000403268
 
ENST00000404885
 
ENST00000407308
 
ENST00000442752
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUSP18-001 ENSP00000333917
ENST00000334679
Q8NEJ0
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Show » Show » 188 21.1 No 0
DUSP18-002 ENSP00000384946
ENST00000403268
F2Z2P2
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Show » Show » 117 12.7 No 0
DUSP18-003 ENSP00000385463
ENST00000404885
Q8NEJ0
Show all »
Show » Show » 188 21.1 No 0
DUSP18-004 ENSP00000386063
ENST00000407308
Q8NEJ0
Show all »
Show » Show » 188 21.1 No 0
DUSP18-007 ENSP00000340795
ENST00000342474
F8VX42
Show all »
Show » Show » 163 18.2 No 0
DUSP18-008 ENSP00000403378
ENST00000442752
Show » 11 1.2 No 0