APBB1

GENE INFORMATION

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Gene name

APBB1 (HGNC Symbol)

Synonyms

Fe65, RIR

Description

Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

6395124 - 6419414

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166313 (version 78.38)

Entrez gene

322

UniProt

O00213 (UniProt - Evidence at protein level)

neXtProt

NX_O00213

Antibodypedia

APBB1 antibodies
 

PROTEIN VIEW

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 « 
 
APBB1-001
 
APBB1-002
 
APBB1-004
 
APBB1-005
 
APBB1-006
 
APBB1-007
 
APBB1-014
 
APBB1-018
 
APBB1-023
 
APBB1-024
 
APBB1-025
 
APBB1-026
 
APBB1-201
 
APBB1-202
 
APBB1-203
 
APBB1-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APBB1-001 ENSP00000311912
ENST00000311051
V9GY97
Show all »
Show » Show » 708 77 No 0
APBB1-002 ENSP00000299402
ENST00000299402
V9GY97
Show all »
Show » Show » 708 77 No 0
APBB1-004 ENSP00000476536
ENST00000529890
V9GY97
Show all »
Show » Show » 262 29.2 No 0
APBB1-005 ENSP00000476442
ENST00000608394
B7Z1L0
Show all »
Show » Show » 451 49.9 No 0
APBB1-006 ENSP00000477022
ENST00000529519
V9GYR7
Show all »
Show » Show » 235 25.7 No 0
APBB1-007 ENSP00000433338
ENST00000530885
V9GY97
Show all »
Show » Show » 488 53.9 Yes 0
APBB1-014 ENSP00000476871
ENST00000608704
B7Z1L0
Show all »
Show » Show » 451 49.9 No 0
APBB1-018 ENSP00000477069
ENST00000609331
B7Z1L0
Show all »
Show » Show » 475 52.7 No 0
APBB1-023 ENSP00000477213
ENST00000609360
O00213
Show all »
Show » Show » 710 77.2 No 0
APBB1-024 ENSP00000476846
ENST00000608655
B7Z1L0
Show all »
Show » Show » 490 54.2 Yes 0
APBB1-025 ENSP00000476646
ENST00000608645
B7Z1L0
Show all »
Show » Show » 451 49.9 No 0
APBB1-026 ENSP00000476647
ENST00000532020
V9GYD5
Show all »
Show » Show » 87 9.7 No 0
APBB1-201 ENSP00000374556
ENST00000389906
J3KPL8
Show all »
Show » Show » 710 77.2 No 0
APBB1-202 ENSP00000483682
ENST00000610474
V9GYR7
Show all »
Show » Show » 451 49.8 No 0
APBB1-203 ENSP00000484493
ENST00000618005
V9GYR7
Show all »
Show » Show » 451 49.8 No 0
APBB1-204 ENSP00000481817
ENST00000621678
V9GYR7
Show all »
Show » Show » 475 52.6 No 0