BTRC

GENERAL INFORMATION

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Gene name

BTRC

Gene description

Beta-transducin repeat containing E3 ubiquitin protein ligase

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB032986
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

BTRC (HGNC Symbol)

Synonyms

beta-TrCP1, betaTrCP, bTrCP, bTrCP1, FBXW1A, Fwd1

Description

Beta-transducin repeat containing E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]

Chromosome

10

Cytoband

q24.32

Chromosome location (bp)

101354033 - 101557321

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166167 (version 78.38)

Entrez gene

8945

UniProt

Q9Y297 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y297

Antibodypedia

BTRC antibodies


PROTEIN BROWSER

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ENST00000370183
 
ENST00000370187
 
ENST00000393441
 
ENST00000408038
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BTRC-001 ENSP00000359206
ENST00000370187
Q9Y297
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Show » Show » 605 68.9 No 0
BTRC-002 ENSP00000385339
ENST00000408038
Q9Y297
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Show » Show » 569 65 No 0
BTRC-005 ENSP00000359202
ENST00000370183
Q5T1W7
Show all »
Show » Show » 191 21.5 No 0
BTRC-201 ENSP00000377088
ENST00000393441
B7Z3H4
Show all »
Show » Show » 579 65.9 No 0