JAM3

GENE INFORMATION

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Gene name

JAM3 (HGNC Symbol)

Synonyms

JAM-C, JAMC

Description

Junctional adhesion molecule 3 (HGNC Symbol)

Entrez gene summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

Chromosome

11

Cytoband

q25

Chromosome location (bp)

134068925 - 134152001

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166086 (version 78.38)

Entrez gene

83700

UniProt

Q9BX67 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BX67

Antibodypedia

JAM3 antibodies
 

PROTEIN VIEW

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JAM3-001
 
JAM3-002
 
JAM3-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

JAM3-001 ENSP00000299106
ENST00000299106
Q9BX67
Show all »
Show » Show » 310 35 Yes 1
JAM3-002 ENSP00000395742
ENST00000441717
Q9BX67
Show all »
Show » Show » 259 29.2 Yes 1
JAM3-005 ENSP00000433206
ENST00000534549
H0YD98
Show all »
Show » Show » 124 14.2 No 0