HTRA1

GENE INFORMATION

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Gene name

HTRA1 (HGNC Symbol)

Synonyms

ARMD7, HtrA, IGFBP5-protease, PRSS11

Description

HtrA serine peptidase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q26.13

Chromosome location (bp)

122461525 - 122514908

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166033 (version 78.38)

Entrez gene

5654

UniProt

Q92743 (UniProt - Evidence at protein level)

neXtProt

NX_Q92743

Antibodypedia

HTRA1 antibodies
 

PROTEIN VIEW

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HTRA1-001
 
HTRA1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HTRA1-001 ENSP00000357980
ENST00000368984
Q92743
Show all »
Show » Show » 480 51.3 Yes 0
HTRA1-002 ENSP00000412676
ENST00000420892
H0Y7G9
Show all »
Show » Show » 221 23.9 No 0