CYP2C19

GENE INFORMATION

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Gene name

CYP2C19 (HGNC Symbol)

Synonyms

CPCJ, CYP2C, P450IIC19

Description

Cytochrome P450, family 2, subfamily C, polypeptide 19 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q23.33

Chromosome location (bp)

94762624 - 94853260

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165841 (version 78.38)

Entrez gene

1557

UniProt

P33261 (UniProt - Evidence at protein level)

neXtProt

NX_P33261

Antibodypedia

CYP2C19 antibodies
 

PROTEIN VIEW

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CYP2C19-001
 
CYP2C19-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP2C19-001 ENSP00000360372
ENST00000371321
P33261
Show all »
Show » Show » 490 55.9 Yes 0
CYP2C19-003 ENSP00000483847
ENST00000480405
Show » Show » 162 18.3 Yes 0