PRDX3

GENE INFORMATION

? »

Gene name

PRDX3 (HGNC Symbol)

Synonyms

AOP-1, AOP1, MER5, SP-22

Description

Peroxiredoxin 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

Chromosome

10

Cytoband

q26.11

Chromosome location (bp)

119167703 - 119178833

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165672 (version 78.38)

Entrez gene

10935

UniProt

P30048 (UniProt - Evidence at protein level)

neXtProt

NX_P30048

Antibodypedia

PRDX3 antibodies
 

PROTEIN VIEW

? »
 
 
 
PRDX3-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRDX3-001 ENSP00000298510
ENST00000298510
P30048
Show all »
Show » Show » 256 27.7 No 0