SLC18A2

GENERAL INFORMATION

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Gene name

SLC18A2

Gene description

Solute carrier family 18 (vesicular monoamine transporter), member 2

Protein class

FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (adrenal gland)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed moderate cytoplasmic positivity. Strong staining was observed in renal tubules, urothelium, placenta, glandular cells in the gastrointestinal tract and endometrium.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA016856
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (adrenal gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SLC18A2 (HGNC Symbol)

Synonyms

SVAT, SVMT, VMAT2

Description

Solute carrier family 18 (vesicular monoamine transporter), member 2 (HGNC Symbol)

Entrez gene summary

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]

Chromosome

10

Cytoband

q25.3

Chromosome location (bp)

117241093 - 117279430

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165646 (version 78.38)

Entrez gene

6571

UniProt

Q05940 (UniProt - Evidence at protein level)

neXtProt

NX_Q05940

Antibodypedia

SLC18A2 antibodies


PROTEIN BROWSER

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ENST00000298472
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC18A2-001 ENSP00000298472
ENST00000298472
Q05940
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