WRN

GENERAL INFORMATION

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Gene name

WRN

Gene description

Werner syndrome, RecQ helicase-like

Protein class

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal cells showed weak to moderate cytoplasmic and/or nuclear positivity. Strong staining was observed in parietal cells of stomach, gall bladder and Purkinje cells. The liver, pancreas, breast, prostate, urothelium, myocytes and lymphoid tissues were negative or weakly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA028661
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

WRN (HGNC Symbol)

Synonyms

RECQ3, RECQL2

Description

Werner syndrome, RecQ helicase-like (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p12

Chromosome location (bp)

31033801 - 31173769

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165392 (version 78.38)

Entrez gene

7486

UniProt

Q14191 (UniProt - Evidence at protein level)

neXtProt

NX_Q14191

Antibodypedia

WRN antibodies


PROTEIN BROWSER

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ENST00000298139
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

WRN-001 ENSP00000298139
ENST00000298139
Q14191
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