Tissue expression of GRIK2 - Summary - The Human Protein Atlas

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GRIK2

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	GRIK2
Gene description	Glutamate receptor, ionotropic, kainate 2
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, thyroid gland)
GTEx:	Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation. Caution, targets protein from more than one gene.
Data reliability	Uncertain based on 3 antibodies. HPA014395 , HPA014623 , CAB022463
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Tissue enhanced (cerebral cortex, thyroid gland)

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enhanced (cerebellum)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	GRIK2 (HGNC Symbol)
Synonyms	GluK2, GLUR6, MRT6
Description	Glutamate receptor, ionotropic, kainate 2 (HGNC Symbol)
Entrez gene summary	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q16.3
Chromosome location (bp)	101398788 - 102070083
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164418 (version 78.38)
Entrez gene	2898
UniProt	Q13002 (UniProt - Evidence at protein level)
neXtProt	NX_Q13002
Antibodypedia	GRIK2 antibodies

PROTEIN BROWSER

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ENST00000318991		ENST00000358361		ENST00000369134		ENST00000369137		ENST00000369138		ENST00000413795		ENST00000421544		ENST00000436862		ENST00000455610

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
GRIK2-001	ENSP00000397026 ENST00000421544	Q13002 Show all » « Hide Q13002 [Direct mapping] Glutamate receptor ionotropic, kainate 2 F8WEZ8 [Target identity:94%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000358130} Q6P3V6 [Target identity:64%; Query identity:100%] GRIK2 protein {ECO:0000313\|EMBL:AAH63814.1} Q9BZ15 [Target identity:23%; Query identity:100%] BA487F5.1 (Glutamate receptor, ionotropic, kainate 2) {ECO:0000313\|EMBL:CAC25104.1} H7C2P5 [Target identity:20%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140} D7RWZ8 [Target identity:3%; Query identity:100%] Glutamate receptor {ECO:0000313\|EMBL:ADH93574.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014)	Show » « Hide GO:0001662 [behavioral fear response] GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006874 [cellular calcium ion homeostasis] GO:0006886 [intracellular protein transport] GO:0007165 [signal transduction] GO:0007215 [glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008066 [glutamate receptor activity] GO:0008328 [ionotropic glutamate receptor complex] GO:0014069 [postsynaptic density] GO:0015277 [kainate selective glutamate receptor activity] GO:0016020 [membrane] GO:0019228 [neuronal action potential] GO:0030054 [cell junction] GO:0030165 [PDZ domain binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032839 [dendrite cytoplasm] GO:0032983 [kainate selective glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035249 [synaptic transmission, glutamatergic] GO:0042391 [regulation of membrane potential] GO:0042734 [presynaptic membrane] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0043113 [receptor clustering] GO:0043195 [terminal bouton] GO:0043204 [perikaryon] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0046328 [regulation of JNK cascade] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0050804 [regulation of synaptic transmission] GO:0050806 [positive regulation of synaptic transmission] GO:0051402 [neuron apoptotic process] GO:0051967 [negative regulation of synaptic transmission, glutamatergic] GO:0060079 [regulation of excitatory postsynaptic membrane potential] GO:0060080 [regulation of inhibitory postsynaptic membrane potential]	908	102.6	Yes	3
GRIK2-002	ENSP00000405596 ENST00000413795	Q13002 Show all » « Hide Q13002 [Direct mapping] Glutamate receptor ionotropic, kainate 2 Q6P3V6 [Target identity:67%; Query identity:100%] GRIK2 protein {ECO:0000313\|EMBL:AAH63814.1} H7C2P5 [Target identity:20%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140} D7RWZ8 [Target identity:3%; Query identity:100%] Glutamate receptor {ECO:0000313\|EMBL:ADH93574.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007215 [glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0015277 [kainate selective glutamate receptor activity] GO:0016020 [membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0032983 [kainate selective glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035249 [synaptic transmission, glutamatergic] GO:0042734 [presynaptic membrane] GO:0045211 [postsynaptic membrane] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0050804 [regulation of synaptic transmission] GO:0050806 [positive regulation of synaptic transmission]	869	98	Yes	3
GRIK2-003	ENSP00000358134 ENST00000369138	Q13002 Show all » « Hide Q13002 [Direct mapping] Glutamate receptor ionotropic, kainate 2 Q6P3V6 [Target identity:65%; Query identity:100%] GRIK2 protein {ECO:0000313\|EMBL:AAH63814.1} H7C2P5 [Target identity:20%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140} D7RWZ8 [Target identity:3%; Query identity:100%] Glutamate receptor {ECO:0000313\|EMBL:ADH93574.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007215 [glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0015277 [kainate selective glutamate receptor activity] GO:0016020 [membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0032983 [kainate selective glutamate receptor complex] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035249 [synaptic transmission, glutamatergic] GO:0042734 [presynaptic membrane] GO:0045211 [postsynaptic membrane] GO:0048172 [regulation of short-term neuronal synaptic plasticity] GO:0050804 [regulation of synaptic transmission] GO:0050806 [positive regulation of synaptic transmission]	892	100.2	Yes	3
GRIK2-004	ENSP00000391988 ENST00000455610	H7BZX7 Show all » « Hide H7BZX7 [Target identity:100%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000391988}	Show » « Hide MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway]	180	20.4	No	0
GRIK2-005	ENSP00000407140 ENST00000436862	H7C2P5 Show all » « Hide H7C2P5 [Target identity:100%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway]	182	20.4	No	1
GRIK2-008	ENSP00000351128 ENST00000358361	G3XAD3 Show all » « Hide G3XAD3 [Target identity:100%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000351128}; Glutamate receptor, ionotropic, kainate 2, isoform CRA_b {ECO:0000313\|EMBL:EAW48447.1} D7RWZ8 [Target identity:9%; Query identity:100%] Glutamate receptor {ECO:0000313\|EMBL:ADH93574.1}	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0016021 [integral component of membrane]	353	39.9	Yes	0
GRIK2-201	ENSP00000313276 ENST00000318991	H7C2P5 Show all » « Hide H7C2P5 [Target identity:21%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway]	854	95.8	No	3
GRIK2-202	ENSP00000358130 ENST00000369134	F8WEZ8 Show all » « Hide F8WEZ8 [Target identity:98%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000358130} Q9BZ15 [Target identity:24%; Query identity:100%] BA487F5.1 (Glutamate receptor, ionotropic, kainate 2) {ECO:0000313\|EMBL:CAC25104.1} H7C2P5 [Target identity:20%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0016020 [membrane] GO:0030054 [cell junction] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway]	870	98.1	No	3
GRIK2-203	ENSP00000358133 ENST00000369137	H7C2P5 Show all » « Hide H7C2P5 [Target identity:21%; Query identity:100%] Glutamate receptor ionotropic, kainate 2 {ECO:0000313\|Ensembl:ENSP00000407140}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0004970 [ionotropic glutamate receptor activity] GO:0005234 [extracellular-glutamate-gated ion channel activity] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0035235 [ionotropic glutamate receptor signaling pathway]	831	93.5	No	3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx