F2RL1

GENERAL INFORMATION

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Gene name

F2RL1

Gene description

Coagulation factor II (thrombin) receptor-like 1

Protein class

G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (colon, skin)

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression, most abundant in gastrointestinal tract and smooth muscle.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
CAB012989
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (colon, skin)

Organ

Expression



GENE INFORMATION

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Gene name

F2RL1 (HGNC Symbol)

Synonyms

GPR11, PAR2

Description

Coagulation factor II (thrombin) receptor-like 1 (HGNC Symbol)

Entrez gene summary

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q13.3

Chromosome location (bp)

76818933 - 76835315

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164251 (version 78.38)

Entrez gene

2150

UniProt

P55085 (UniProt - Evidence at protein level)

neXtProt

NX_P55085

Antibodypedia

F2RL1 antibodies


PROTEIN BROWSER

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ENST00000296677
 
ENST00000514165
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F2RL1-001 ENSP00000296677
ENST00000296677
P55085
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Show » Show » 397 44.1 Yes 7
F2RL1-002 ENSP00000425622
ENST00000514165
D6RJH3
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Show » Show » 112 12.9 No 3