HEYL

GENERAL INFORMATION

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Gene name

HEYL

Gene description

Hes-related family bHLH transcription factor with YRPW motif-like

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Bone marrow poetic cells showed moderate nuclear positivity. Plasma and endothelial cells displayed moderate positivity. Remaining normal cells were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA001438
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HEYL (HGNC Symbol)

Synonyms

bHLHb33, HESR3, HEY3

Description

Hes-related family bHLH transcription factor with YRPW motif-like (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p34.2

Chromosome location (bp)

39624153 - 39639945

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163909 (version 78.38)

Entrez gene

26508

UniProt

Q9NQ87 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9NQ87

Antibodypedia

HEYL antibodies


PROTEIN BROWSER

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ENST00000372852
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HEYL-001 ENSP00000361943
ENST00000372852
Q9NQ87
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