PPBP

GENE INFORMATION

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Gene name

PPBP (HGNC Symbol)

Synonyms

b-TG1, Beta-TG, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, NAP-2-L1, PBP, SCYB7, TGB, TGB1, THBGB1

Description

Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]

Chromosome

4

Cytoband

q13.3

Chromosome location (bp)

73987038 - 73988197

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163736 (version 78.38)

Entrez gene

5473

UniProt

P02775 (UniProt - Evidence at protein level)

neXtProt

NX_P02775

Antibodypedia

PPBP antibodies
 

PROTEIN VIEW

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PPBP-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PPBP-001 ENSP00000296028
ENST00000296028
P02775
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