APBB2 - Gene info - The Human Protein Atlas

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APBB2

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	APBB2 (HGNC Symbol)
Synonyms	FE65L, FE65L1, MGC35575
Description	Amyloid beta (A4) precursor protein-binding, family B, member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Chromosome	4
Cytoband
Chromosome location (bp)	40810027 - 41216714
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000163697 (version 78.38)
Entrez gene	323
UniProt	Q92870 (UniProt - Evidence at protein level)
neXtProt	NX_Q92870
Antibodypedia	APBB2 antibodies

PROTEIN VIEW

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APBB2-001		APBB2-002		APBB2-003		APBB2-006		APBB2-007		APBB2-010		APBB2-012		APBB2-016		APBB2-018		APBB2-019		APBB2-020		APBB2-023		APBB2-025		APBB2-026		APBB2-027		APBB2-028		APBB2-029		APBB2-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
APBB2-001	ENSP00000426018 ENST00000513140	Q92870 Show all » « Hide Q92870 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 2 B4DJ88 [Target identity:63%; Query identity:100%] cDNA FLJ52628, highly similar to Amyloid beta A4 protein-binding family B member 2 (Fe65-like protein) {ECO:0000313\|EMBL:BAG58750.1} D6RB55 [Target identity:19%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000424414} D6RB00 [Target identity:9%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000424579} D6RAE0 [Target identity:3%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000422723} D6RDY3 [Target identity:3%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000425202}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] GO:0008134 [transcription factor binding] GO:0016020 [membrane] GO:0030027 [lamellipodium] GO:0030308 [negative regulation of cell growth] GO:0030426 [growth cone] GO:0035556 [intracellular signal transduction] GO:0045202 [synapse]	736	80.9	No	0
APBB2-002	ENSP00000295974 ENST00000295974	Q92870 Show all » « Hide Q92870 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 2 Q5I0G1 [Target identity:48%; Query identity:100%] APBB2 protein {ECO:0000313\|EMBL:AAH88372.1} A8K1C3 [Target identity:43%; Query identity:100%] cDNA FLJ75171, highly similar to Homo sapiens amyloid beta (A4) protein-binding, family B,member 2 (Fe65-like) (APBB2), mRNA {ECO:0000313\|EMBL:BAF82527.1} D6RB55 [Target identity:18%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000424414} D6RD19 [Target identity:13%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000427107} D6RAJ4 [Target identity:12%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421751} D6RGD4 [Target identity:11%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421301} D6RB00 [Target identity:8%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000424579} D6RAE0 [Target identity:3%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000422723} D6RDY3 [Target identity:3%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000425202}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] GO:0008134 [transcription factor binding] GO:0016020 [membrane] GO:0030027 [lamellipodium] GO:0030308 [negative regulation of cell growth] GO:0030426 [growth cone] GO:0035556 [intracellular signal transduction] GO:0045202 [synapse]	758	83.4	No	0
APBB2-003	ENSP00000427211 ENST00000508593	Q92870 Show all » « Hide Q92870 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 2 Q5I0G1 [Target identity:48%; Query identity:100%] APBB2 protein {ECO:0000313\|EMBL:AAH88372.1} A8K1C3 [Target identity:43%; Query identity:100%] cDNA FLJ75171, highly similar to Homo sapiens amyloid beta (A4) protein-binding, family B,member 2 (Fe65-like) (APBB2), mRNA {ECO:0000313\|EMBL:BAF82527.1} D6RB55 [Target identity:18%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000424414} D6RD19 [Target identity:13%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000427107} D6RAJ4 [Target identity:12%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421751} D6RGD4 [Target identity:11%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421301} D6RB00 [Target identity:8%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000424579} D6RAE0 [Target identity:3%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000422723} D6RDY3 [Target identity:3%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000425202}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001540 [beta-amyloid binding] GO:0001764 [neuron migration] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] GO:0007411 [axon guidance] GO:0008134 [transcription factor binding] GO:0016020 [membrane] GO:0030027 [lamellipodium] GO:0030198 [extracellular matrix organization] GO:0030308 [negative regulation of cell growth] GO:0030426 [growth cone] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0045202 [synapse]	759	83.4	No	0
APBB2-006	ENSP00000427307 ENST00000513611	Q5I0G1 Show all » « Hide Q5I0G1 [Target identity:50%; Query identity:100%] APBB2 protein {ECO:0000313\|EMBL:AAH88372.1} A8K1C3 [Target identity:45%; Query identity:100%] cDNA FLJ75171, highly similar to Homo sapiens amyloid beta (A4) protein-binding, family B,member 2 (Fe65-like) (APBB2), mRNA {ECO:0000313\|EMBL:BAF82527.1} D6RB55 [Target identity:19%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000424414} D6RD19 [Target identity:14%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000427107} D6RAJ4 [Target identity:13%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421751} D6RGD4 [Target identity:11%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421301} D6RDY3 [Target identity:3%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000425202}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	728	80	No	0
APBB2-007	ENSP00000425802 ENST00000502841	Q92870 Show all » « Hide Q92870 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 2 D6RD19 [Target identity:48%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000427107} D6RAJ4 [Target identity:45%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421751} D6RGD4 [Target identity:41%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421301}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] GO:0008134 [transcription factor binding] GO:0016020 [membrane] GO:0030027 [lamellipodium] GO:0030308 [negative regulation of cell growth] GO:0030426 [growth cone] GO:0035556 [intracellular signal transduction] GO:0045202 [synapse]	210	23.5	No	0
APBB2-010	ENSP00000422723 ENST00000508676	D6RAE0 Show all » « Hide D6RAE0 [Target identity:100%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000422723}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		27	2.7	No	0
APBB2-012	ENSP00000421539 ENST00000506352	G5E9Y1 Show all » « Hide G5E9Y1 [Target identity:100%; Query identity:100%] Amyloid beta (A4) protein-binding, family B, member 2 (Fe65-like), isoform CRA_c {ECO:0000313\|EMBL:EAW92977.1}; Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421539} B4DJ88 [Target identity:63%; Query identity:100%] cDNA FLJ52628, highly similar to Amyloid beta A4 protein-binding family B member 2 (Fe65-like protein) {ECO:0000313\|EMBL:BAG58750.1} Q5I0G1 [Target identity:49%; Query identity:100%] APBB2 protein {ECO:0000313\|EMBL:AAH88372.1} A8K1C3 [Target identity:44%; Query identity:100%] cDNA FLJ75171, highly similar to Homo sapiens amyloid beta (A4) protein-binding, family B,member 2 (Fe65-like) (APBB2), mRNA {ECO:0000313\|EMBL:BAF82527.1} D6RB55 [Target identity:18%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000424414} D6RD19 [Target identity:13%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000427107} D6RAJ4 [Target identity:12%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421751} D6RGD4 [Target identity:11%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421301} D6RB00 [Target identity:9%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000424579} D6RAE0 [Target identity:3%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000422723} D6RDY3 [Target identity:3%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000425202}	Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	737	81	No	0
APBB2-016	ENSP00000421205 ENST00000503503		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		10	1	No	0
APBB2-018	ENSP00000424579 ENST00000508707	D6RB00 Show all » « Hide D6RB00 [Target identity:100%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000424579} D6RAE0 [Target identity:39%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000422723} D6RDY3 [Target identity:38%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000425202}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		68	7.3	No	0
APBB2-019	ENSP00000425202 ENST00000503264	D6RDY3 Show all » « Hide D6RDY3 [Target identity:100%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000425202}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		26	2.7	No	0
APBB2-020	ENSP00000424414 ENST00000509446	D6RB55 Show all » « Hide D6RB55 [Target identity:100%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000424414} D6RDY3 [Target identity:18%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000425202}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		140	15.1	No	0
APBB2-023	ENSP00000425121 ENST00000513493		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	142	15.9	No	0
APBB2-025	ENSP00000423765 ENST00000504305	Q92870 Show all » « Hide Q92870 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 2 D6RD19 [Target identity:48%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000427107} D6RAJ4 [Target identity:45%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421751} D6RGD4 [Target identity:41%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421301}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] GO:0008134 [transcription factor binding] GO:0016020 [membrane] GO:0030027 [lamellipodium] GO:0030308 [negative regulation of cell growth] GO:0030426 [growth cone] GO:0035556 [intracellular signal transduction] GO:0045202 [synapse]	210	23.5	No	0
APBB2-026	ENSP00000427107 ENST00000510670	D6RD19 Show all » « Hide D6RD19 [Target identity:100%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000427107} D6RAJ4 [Target identity:93%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421751} D6RGD4 [Target identity:85%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421301}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	102	11.3	No	0
APBB2-027	ENSP00000421301 ENST00000513516	D6RGD4 Show all » « Hide D6RGD4 [Target identity:100%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421301}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	87	9.6	No	0
APBB2-028	ENSP00000421751 ENST00000514920	D6RAJ4 Show all » « Hide D6RAJ4 [Target identity:100%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421751} D6RGD4 [Target identity:91%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421301}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	95	10.5	No	0
APBB2-029	ENSP00000426429 ENST00000512510	H0YA92 Show all » « Hide H0YA92 [Target identity:99%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000426429} D6RD19 [Target identity:56%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000427107} D6RAJ4 [Target identity:52%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421751} D6RGD4 [Target identity:48%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421301}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	180	20.2	No	0
APBB2-201	ENSP00000439357 ENST00000543538	Q92870 Show all » « Hide Q92870 [Direct mapping] Amyloid beta A4 precursor protein-binding family B member 2 D6RD19 [Target identity:48%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000427107} D6RAJ4 [Target identity:45%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421751} D6RGD4 [Target identity:41%; Query identity:100%] Amyloid beta A4 precursor protein-binding family B member 2 {ECO:0000313\|Ensembl:ENSP00000421301}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007050 [cell cycle arrest] GO:0008134 [transcription factor binding] GO:0016020 [membrane] GO:0030027 [lamellipodium] GO:0030308 [negative regulation of cell growth] GO:0030426 [growth cone] GO:0035556 [intracellular signal transduction] GO:0045202 [synapse]	210	23.5	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.