Tissue expression of MSX1 - Summary - The Human Protein Atlas

GENERAL INFORMATION

? »

Protein class

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Predicted localization

Protein localization predicted from several bioinformatic algorithms. More info...

Number of transcripts

Number of protein-coding transcribed from this gene as defined by Ensembl.

Gene name

MSX1

Gene description

Msh homeobox 1

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

ANTIBODY RELIABILITY

? »

Data reliability description

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable.

Data reliability

Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB026198

GENE INFORMATION

? »

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

MSX1 (HGNC Symbol)

Synonyms

HOX7, HYD1, OFC5

Description

Msh homeobox 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p16.2

Chromosome location (bp)

4859666 - 4863936

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163132 (version 78.38)

Entrez gene

4487

UniProt

P28360 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MSX1-001

ENSP00000372170
ENST00000382723

P28360
Show all » « Hide

P28360 [Direct mapping]
Homeobox protein MSX-1
E9KXZ6 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64910.1}
E9KXX4 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64888.1}
E9KXZ5 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64909.1}
E9KXZ4 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64908.1}
E9KXZ3 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64907.1}
E9KXZ2 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64906.1}
E9KXZ1 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64905.1}
E9KXZ0 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64904.1}
E9KXY9 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64903.1}
E9KXY8 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64902.1}
E9KXY7 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64901.1}
E9KXY6 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64900.1}
E9KXY5 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64899.1}
E9KXY4 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64898.1}
E9KXY3 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64897.1}
E9KXY2 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64896.1}
E9KXY1 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64895.1}
E9KXY0 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64894.1}
E9KXX9 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64893.1}
E9KXX8 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64892.1}
E9KXX7 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64891.1}
E9KXX6 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64890.1}
E9KXX5 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64889.1}
E9KXX3 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64887.1}
E9KY08 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64922.1}
E9KY19 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64933.1}
E9KY18 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64932.1}
E9KY17 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64931.1}
E9KY16 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64930.1}
E9KY15 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64929.1}
E9KY14 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64928.1}
E9KY13 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64927.1}
E9KY12 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64926.1}
E9KY11 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64925.1}
E9KY10 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64924.1}
E9KY09 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64923.1}
E9KXZ7 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64911.1}
E9KY07 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64921.1}
E9KY06 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64920.1}
E9KY05 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64919.1}
E9KY04 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64918.1}
E9KY03 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64917.1}
E9KY02 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64916.1}
E9KY01 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64915.1}
E9KY00 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64914.1}
E9KXZ9 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64913.1}
E9KXZ8 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64912.1}
E9KXT8 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64852.1}
E9KXU9 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64863.1}
E9KXU8 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64862.1}
E9KXU7 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64861.1}
E9KXU6 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64860.1}
E9KXU5 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64859.1}
E9KXU4 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64858.1}
E9KXU3 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64857.1}
E9KXU2 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64856.1}
E9KXU1 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64855.1}
E9KXU0 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64854.1}
E9KXT9 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64853.1}
E9KXV0 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64864.1}
E9KXT7 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64851.1}
E9KXT6 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64850.1}
E9KXT5 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64849.1}
E9KXT4 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64848.1}
E9KXT3 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64847.1}
E9KXT2 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64846.1}
E9KXT1 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64845.1}
E9KXT0 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64844.1}
E9KXS9 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64843.1}
E9KXS8 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64842.1}
E9KXS7 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64841.1}
E9KXW1 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64875.1}
E9KXX2 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64886.1}
E9KXX1 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64885.1}
E9KXX0 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64884.1}
E9KXW9 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64883.1}
E9KXW8 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64882.1}
E9KXW7 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64881.1}
E9KXW6 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64880.1}
E9KXW5 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64879.1}
E9KXW4 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64878.1}
E9KXW3 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64877.1}
E9KXW2 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64876.1}
E9KXS6 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64840.1}
E9KXW0 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64874.1}
E9KXV9 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64873.1}
E9KXV8 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64872.1}
E9KXV7 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64871.1}
E9KXV6 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64870.1}
E9KXV5 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64869.1}
E9KXV4 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64868.1}
E9KXV3 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64867.1}
E9KXV2 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64866.1}
E9KXV1 [Target identity:48%; Query identity:100%]
Homeobox protein MSX-1 {ECO:0000313|EMBL:ADR64865.1}

Show » « Hide

Predicted intracellular proteins
Transcription factors
Helix-turn-helix domains
Disease related genes

Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000902 [cell morphogenesis]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000982 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity]
GO:0001227 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription]
GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001701 [in utero embryonic development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002039 [p53 binding]
GO:0003007 [heart morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0008285 [negative regulation of cell proliferation]
GO:0009952 [anterior/posterior pattern specification]
GO:0010463 [mesenchymal cell proliferation]
GO:0021983 [pituitary gland development]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030308 [negative regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030509 [BMP signaling pathway]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0030900 [forebrain development]
GO:0030901 [midbrain development]
GO:0034504 [protein localization to nucleus]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0035880 [embryonic nail plate morphogenesis]
GO:0042474 [middle ear morphogenesis]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042476 [odontogenesis]
GO:0042481 [regulation of odontogenesis]
GO:0042733 [embryonic digit morphogenesis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048863 [stem cell differentiation]
GO:0050821 [protein stabilization]
GO:0051154 [negative regulation of striated muscle cell differentiation]
GO:0051216 [cartilage development]
GO:0060021 [palate development]
GO:0060325 [face morphogenesis]
GO:0060349 [bone morphogenesis]
GO:0060536 [cartilage morphogenesis]
GO:0061180 [mammary gland epithelium development]
GO:0061312 [BMP signaling pathway involved in heart development]
GO:0071316 [cellular response to nicotine]
GO:0090427 [activation of meiosis]
GO:1902255 [positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
GO:2001055 [positive regulation of mesenchymal cell apoptotic process]

303

31.5

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.